Hostname: page-component-745bb68f8f-v2bm5 Total loading time: 0 Render date: 2025-02-11T20:43:20.862Z Has data issue: false hasContentIssue false
  • English
  • Français

Power output of fast and slow skeletal muscles of mdx (dystrophic) and control mice after clenbuterol treatment

Published online by Cambridge University Press:  25 January 2001

Gordon S. Lynch ,
Richard T. Hinkle  and
John A. Faulkner
Gordon S. Lynch
Affiliation:
Institute of Gerontology and Departments of Physiology and Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109-2007, USA
Richard T. Hinkle
Affiliation:
Institute of Gerontology and Departments of Physiology and Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109-2007, USA
John A. Faulkner
Affiliation:
Institute of Gerontology and Departments of Physiology and Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109-2007, USA
Get access

Abstract

The mdx mouse is the most commonly used animal model for Duchenne muscular dystrophy. We tested the null hypothesis that 20 weeks of clenbuterol treatment (∼2 mg kg-1 day-1) of mdx and control mice would have no effect on the absolute and specific force (Po, kN m-2) and absolute and normalised power output (W kg-1) of extensor digitorum longus (EDL) and soleus muscles. For mdx and control mice, clenbuterol treatment produced modest increases in the mass of the two muscles but did not increase absolute or specific force or normalised power output. For absolute power output, only the EDL muscles of mdx mice showed a difference following treatment, with the power output of treated mice being 118 % that of the untreated mice. The modest effects of clenbuterol treatment on the dynamic properties of skeletal muscle provide little support for any improvement in muscle function for the dystrophic condition. Experimental Physiology (2000) 85.3, 295-299.

Type
Research Article
Information
Experimental Physiology , Volume 85 , Issue 3 , May 2000 , pp. 295 - 299
Copyright
© The Physiological Society 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)