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Import of nuclear-encoded proteins into mitochondria

Published online by Cambridge University Press:  09 January 2003

Diana Stojanovski ,
Amelia J. Johnston ,
Illo Streimann ,
Nicholas J. Hoogenraad  and
Michael T. Ryan
Diana Stojanovski
Affiliation:
Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
Amelia J. Johnston
Affiliation:
Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
Illo Streimann
Affiliation:
Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
Nicholas J. Hoogenraad
Affiliation:
Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
Michael T. Ryan
Affiliation:
Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
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Abstract

The majority of mitochondrial proteins are encoded by nuclear genes, synthesized in the cytosol and subsequently imported into mitochondria through protein translocation machineries of the outer and inner membranes. In this review, we discuss the arrangement of the various translocation complexes and the function of individual import components. We also outline the various targeting pathways that preproteins can take in order to reach their appropriate sub-mitochondrial compartment. Experimental Physiology (2003) 88.1, 57-64.

Type
Special Review Series - Biogenesis and Physiological Adaptation of Mitochondria
Information
Experimental Physiology , Volume 88 , Issue 1 , January 2003 , pp. 57 - 64
Copyright
© The Physiological Society 2003

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