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ICln, AN ION CHANNEL-FORMING PROTEIN ASSOCIATED WITH CELL VOLUME REGULATION

Published online by Cambridge University Press:  04 January 2001

M. GSCHWENTNER ,
J. FÜRST ,
M. RITTER ,
C. BAZZINI ,
E. WÖLL ,
A. DIENSTL ,
M. JAKAB ,
M. KÖNIG ,
E. SCANDELLA  and
J. RUDZKI
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M. GSCHWENTNER
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
J. FÜRST
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
M. RITTER
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
C. BAZZINI
Affiliation:
Department of General Physiology and Biochemistry, University of Milan, Via Celoria 26, I-20133 Milan, Italy
E. WÖLL
Affiliation:
Department of Internal Medicine, University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria
A. DIENSTL
Affiliation:
Department of Internal Medicine, University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria
M. JAKAB
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
M. KÖNIG
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
E. SCANDELLA
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
J. RUDZKI
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
G. BOTTA
Affiliation:
Department of General Physiology and Biochemistry, University of Milan, Via Celoria 26, I-20133 Milan, Italy
G. MEYER
Affiliation:
Department of General Physiology and Biochemistry, University of Milan, Via Celoria 26, I-20133 Milan, Italy
F. LANG
Affiliation:
Department of Physiology, University of Tübingen, Gmelinstraße 5, D-72076 Tübingen, Germany
P. DEETJEN
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
M. PAULMICHL
Affiliation:
Department of Physiology, University of Innsbruck, Fritz-Pregl-Straße 3, A-6020 Innsbruck, Austria
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Abstract

It is not resolved whether the anionic channel involved in volume regulation after cell swelling comprises one or more subunits. Moreover, it remains to be determined which of the different proteins cloned so far, for which an involvement in cell volume regulation has been postulated, is the ideal candidate. In this review, we consider the role of the ICln protein, cloned from MDCK cells, in cell volume regulation.

Type
Review Article
Information
Experimental Physiology , Volume 84 , Issue 6 , November 1999 , pp. 1023 - 1031
Copyright
© The Physiological Society 1999

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