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The effect of acidosis on the ECG of the rat heart

Published online by Cambridge University Press:  31 July 2001

A. Aberra ,
K. Komukai ,
F. C. Howarth  and
C. H. Orchard
A. Aberra
Affiliation:
School of Biomedical Sciences, University of Leeds, Leeds LS2 9NL, UK, Faculty of Medicine, Addis Ababa University, PO Box 9886, Addis Ababa, Ethiopia and Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666,
K. Komukai
Affiliation:
School of Biomedical Sciences, University of Leeds, Leeds LS2 9NL, UK, Faculty of Medicine, Addis Ababa University, PO Box 9886, Addis Ababa, Ethiopia and Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666,
F. C. Howarth
Affiliation:
School of Biomedical Sciences, University of Leeds, Leeds LS2 9NL, UK, Faculty of Medicine, Addis Ababa University, PO Box 9886, Addis Ababa, Ethiopia and Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666,
C. H. Orchard
Affiliation:
School of Biomedical Sciences, University of Leeds, Leeds LS2 9NL, UK, Faculty of Medicine, Addis Ababa University, PO Box 9886, Addis Ababa, Ethiopia and Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666,
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Abstract

We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart. Experimental Physiology (2001) 86.1, 27-31.

Type
Research Article
Information
Experimental Physiology , Volume 86 , Issue 1 , January 2001 , pp. 27 - 31
Copyright
© The Physiological Society 2001

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