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A putative alternatively spliced variant of the P2X1 purinoreceptor in human bladder

Published online by Cambridge University Press:  25 January 2001

L. A. Hardy ,
I. J. Harvey ,
P. Chambers  and
J. I. Gillespie
L. A. Hardy
Affiliation:
Department of Surgery, School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
I. J. Harvey
Affiliation:
Department of Surgery, School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
P. Chambers
Affiliation:
Department of Surgery, School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
J. I. Gillespie
Affiliation:
Department of Surgery, School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
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Abstract

Activation of purinergic P2X receptors, putatively P2X1, may be important in the initiation of contraction in human detrusor. Purinergic transmission may be more important in muscle taken from patients with bladder instability. In this study the presence of the P2X1 receptor subtype was confirmed using RT-PCR. In addition, the results indicate, at the mRNA level, the presence of a splice variant of P2X1 that is lacking part of the second transmembrane domain. It is therefore possible that human bladder expresses multiple isoforms of the P2X1 receptor which may be potential sites for modifying or regulating putative purinergic activation of the human bladder.

Type
Rapid Communication
Information
Experimental Physiology , Volume 85 , Issue 4 , July 2000 , pp. 461 - 463
Copyright
© The Physiological Society 2000

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