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THE INFLUENCE OF STREPTOZOTOCIN-INDUCED DIABETES AND THE ANTIHYPERGLYCAEMIC AGENT METFORMIN ON THE CONTRACTILE CHARACTERISTICS AND THE MEMBRANE POTENTIAL OF THE RAT DIAPHRAGM

Published online by Cambridge University Press:  03 January 2001

MICHELLE McGUIRE  and
MARY MacDERMOTT
MICHELLE McGUIRE
Affiliation:
Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
MARY MacDERMOTT
Affiliation:
Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
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Abstract

After 2 months of streptozotocin-induced diabetes in rats, the membrane potential of the diaphragm muscle when measured in vitro at 30¡C was unchanged but the tetanic tension, the half-relaxation time of the isometric twitch and the fatigue resistance were each reduced. Treatment of the diabetic rats with the antihyperglycaemic agent metformin prevented the decrease in half-relaxation time and the greater degree of fatigue in the diaphragms. The possibility that changes in H+ and cyclic AMP concentrations in the diabetic muscles contributed to the decreased contractile function and that metformin acted by attenuating these changes is discussed.

Type
Research Article
Information
Experimental Physiology , Volume 83 , Issue 4 , July 1998 , pp. 481 - 487
Copyright
© The Physiological Society 1998

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