In a field experiment initiated in the 1972/73 rabi season (November–March) on an acidic soil in the western Himalayas of India, continuous cropping for 25 years with nitrogen fertilizer alone reduced the grain yields of maize (Zea mays) and wheat (Triticum aestivum) to almost zero. Based on five-year moving average values, the application of 100% NP resulted in a reduction of grain yields of maize and wheat crops by 67 and 19% respectively during 1994 to1998 compared with 1973 to 1977. The crops did not respond to K application during the initial years of cropping, but a significant reduction in crop yields was observed in the absence of K after five years of continuous cropping. With the integrated use of chemical fertilizers (100% NPK) and farmyard manure, the pooled grain yields of 25 years were about 4600 and 3300 kg ha−1 for maize and wheat respectively. Corresponding yields with the use of chemical fertilizers and lime (100% NPK + lime) were 4000 and 3100 kg ha−1 respectively. The use of nitrogenous fertilizer alone aggravated the problem of soil acidity by lowering the pH from 5.8 to 4.7 after 25 years. In almost all the treatments, the organic carbon content increased: a marginal decrease occurred in the 100% N and control plots. Even under optimum application rates, the available N and K status decreased with time. Again with the exception of the control plots, the contents of the Diphenyl Triamine Penta Acetic Acid-extractable micronutrients were sufficiently high for the crops in all the treatments. The available sulphur decreased with the use of di-ammonium phosphate as the P source, which drastically reduced the yields of both crops. In the N-alone treatment the weed flora also changed with the change in soil environment. There is a need to review fertilizer recommendations in this region of India.