For some decades, astronomy and astrophysics have undergone a technological and conceptual revolution. Supported by ever more powerful telescopes and instruments on the ground and in space, the volume and quality of new insights is incredible, both in terms of physical understanding of individual celestial objects and the grand evolutionary scheme. New and powerful observational facilities such as the ESO Very Large Telescope (VLT) are opening new horizons, from the nearby solar system to the corners of the Milky Way galaxy in which we live and, not least, towards the vast expanses in time and space of the remote and early Universe. The next generation of ultra-sensitive optical-infrared telescopes such as Herschel and ALMA will be ready within this decade and concepts are being elaborated for the construction of super-giant telescopes like the 100 m optical/IR OWL, the ‘Overwhelmingly Large telescope’. With these impressive developments, and in a true spirit of exploration, astronomers can now look forward to great research opportunities, in a resounding manifestation of the continuous drive towards a better understanding of our cosmic surroundings and of our own origins, so characteristic for enlightened humankind of every age.