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On Stem Cells, Organoids and Human Disease

Published online by Cambridge University Press:  02 October 2019

Hans Clevers
Hans Clevers*
Affiliation:
Hubrecht Institute, Oncode Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT Utrecht, the Netherlands. Email: [email protected]
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Abstract

Stem cells build our bodies during development, starting from a fertilized oocyte. Subsequently, they maintain and repair our organs for a lifetime. Thus, stem cells hold the promise of eternal life. While this may still be in the distant future, stem cells are rapidly changing the face of biomedical science and are finding applications in the clinic. In this article, I discuss the principles of stem cell biology and the mini-organs that can be grown from stem cells in a petri dish.

Type
AE 2018 Annual Conference Lectures
Information
European Review , Volume 28 , Issue 1 , February 2020 , pp. 1 - 5
Copyright
© Academia Europaea 2019 

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References

Cheng, H and Leblond, CP (1974) Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. American Journal of Anatomy 141, 461–479.CrossRefGoogle Scholar
Clevers, H (2013) The intestinal crypt, a prototype stem cell compartment. Cell 154, 274–284. doi: 10.1016/j.cell.2013.07.004.CrossRefGoogle Scholar
Clevers, H (2015) What is an adult stem cell? Science 350, 1319–1320. doi: 10.1126/science.aad7016.CrossRefGoogle Scholar
Clevers, H (2016) Modeling development and diseases with organoids. Cell 165, 1586–1597. doi: 10.1016/j.cell.2016.05.082.CrossRefGoogle Scholar
Lancaster, MA, Renner, M, Martin, CA, Wenzel, D, Bicknell, LS, Hurles, ME, Homfray, T, Penninger, JM, Jackson, AP and Knoblich, JA (2013) Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379.CrossRefGoogle Scholar
Stevens, CE and Leblond, CP (1947) Rate of renewal of the cells of the intestinal epithelium in the rat. The Anatomical Record 97, 373.Google Scholar
Takasato, M, Er, PX, Chiu, HS, Maier, B, Baillie, GJ, Ferguson, C, Parton, RG, Wolvetang, EJ, Roost, MS, Lopes, SM and Little, MH (2016) Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 536, 238. doi: 10.1038/nature17982.CrossRefGoogle Scholar
Till, JE and McCulloch, EA (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiation Research 14, 213–222.CrossRefGoogle Scholar
Thomas, ED, Lochte, HL Jr., Lu, WC and Ferrebee, JW (1957) Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. New England Journal of Medicine 257, 491–496.CrossRefGoogle Scholar