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How Drugs can Stimulate Psychic Functions – Using Caffeine as an Example

Published online by Cambridge University Press:  02 May 2012

Bertil B. Fredholm
Bertil B. Fredholm
Affiliation:
Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden. Email: [email protected]
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Abstract

Mind–Brain dualism is still a hotly debated issue.1,2 I am neither qualified nor inclined to outline the intricacies of these philosophical controversies. However, one aspect deserves attention by a pharmacologist: some forms of very strict dualism have problems in dealing with the fact that drugs can alter cognitive states. It also seems to me that the challenge would become even stronger if one could demonstrate not only that a drug can alter a mental state, but also provide a clear cellular mechanism of how this is brought about. This is what I will try to do in this brief essay. I will not, however, even try to consider how the effect on specific brain cells is translated into something that we perceive as mental.

Type
Brains and Robots
Information
European Review , Volume 20 , Issue 3 , 02 May 2012 , pp. 316 - 323
Copyright
Copyright © Academia Europaea 2012

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References

1.Chalmers, D. (1997) The Conscious Mind (Oxford, UK: Oxford University Press).Google Scholar
2.Dennett, D. (1991) Consciousness Explained (Little, Brown).Google Scholar
3.Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A. and Zvartau, E. E. (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews, 51, pp. 83–133.Google ScholarPubMed
4.Wei, C. J., Singer, P., Coelho, J., Boison, D., Feldon, J., Yee, B. K. and Chen, J. F. (2011) Selective inactivation of adenosine A2A receptors in striatal neurons enhances working memory and reversal learning. Learning & Memory, 18, pp. 459–474.CrossRefGoogle ScholarPubMed
5.Yang, J., Chen, J. and Fredholm, B. B. (2009) Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. American Journal of Physiology Heart and Circulatory Physiology, 296, pp. H1141–H1149.CrossRefGoogle ScholarPubMed
6.Lazarus, M., Shen, H., Cherasse, Y., Qu, W.-M., Huang, Z.-L., Bass, C., Semba, K., Fredholm, B. B., Boison, D., Hayaishi, O., Urade, Y. and Chen, J.-F. (2011) Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. Journal of Neuroscience, 31, pp. 10067–10075.CrossRefGoogle ScholarPubMed
7.Gangwisch, J. E. (2009) Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obesity Reviews, 10, pp. 37–45.CrossRefGoogle ScholarPubMed
8.Huang, Z. L., Urade, Y. and Hayaishi, O. (2011) The role of adenosine in the regulation of sleep. Current Topics in Medicinal Chemistry, 11, pp. 1047–1057.CrossRefGoogle ScholarPubMed
9.Porkka-Heiskanen, T. (2011) Methylxanthines and sleep. Handbook of Experimental Pharmacology, 200, pp. 331–348.CrossRefGoogle Scholar
10.Ishimori, K. (1909) True cause of sleep: a hypnogenic substance as evidenced in the brain of sleep-deprived animals. Tokyo Igakkai Zasshi, 23, pp. 429–459.Google Scholar
11.Mathieu-Levy, N. (1967) Metabolisme de quelques hypnotiques (hydrate de chloral, trichlorethanol, mebubarbital, thiopental) chez le rat, au cours du sommeil experimental potentialise par l'acide adenosine triphosphorique. Therapie, 22, pp. 945–956.Google Scholar
12.Radulovacki, M., Miletich, R. S. and Green, R. D. (1982) N6 (L-phenylisopropyl) adenosine (L-PHA) increases slow-wave sleep (S2) and decreases wakefulness in rats,. Brain Research, 246, pp. 178–180.CrossRefGoogle ScholarPubMed
13.Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjorkum, A. A., Greene, R. W. and McCarley, R. W. (1997) Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science, 276, pp. 1265–1268.CrossRefGoogle ScholarPubMed
14.Saper, C. B. (2006) Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms. Progress in Brain Research, 153, pp. 243–252.CrossRefGoogle ScholarPubMed