Since the Enlightenment, the history of science has been enlisted to show the unity and distinctiveness of Europe. This paper, written on the occasion of the award of the 2005 Erasmus Prize to historians of science Simon Schaffer and Steven Shapin, traces the intertwined narratives of the history of science and European modernity from the 18th century to the present. Whether understood as triumph or tragedy (and there have been eloquent proponents of both views), the Scientific Revolution has been portrayed as Europe's decisive break with tradition – the first such break in world history and the model for all subsequent epics of modernization in other cultures. The paper concludes with reflections on how a new history of science, exemplified in the work of Shapin and Schaffer, may transform the self-image of Europe and conceptions of truth itself.