Change in European cultural history has, for a long period, been discussed through two interrelated notions, that of science and that of history. This paper traces the various stages of this discussion from Antiquity to the present day from the point of view of history. Two reoccurring and paradigmatic characters of mythological descent, Odysseus and Prometheus, illustrate how history as a realm for human responsibility and future planning has established itself as a specific European construct, with the 18th century as its final breakthrough in practical and ideological terms. A close analysis of Leonardo da Vinci's drawing the Vitruvian Man, in statu nascendi, shows how the individual human being carrying the obligations and the promises of this history, is envisioned. The final remarks underline the importance of scientific knowledge in the concrete shaping of this responsibility and a plea for an increased cooperation across the disciplines.