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Wake therapy yields sustained response and remission. A rater-blind 9 weeks controlled study using a chronotherapeutic intervention compared to exercise

Published online by Cambridge University Press:  16 April 2020

K. Martiny ,
E. Refsgaard ,
V. Lund ,
M. Lunde  and
P. Bech
K. Martiny
Affiliation:
Mental Health Center Copenhagen, University Hospitals Copenhagen, Copenhagen, Denmark
E. Refsgaard
Affiliation:
Mental Health Center North Zealand, Psychiatric Research Unit, Hilleroed, Denmark
V. Lund
Affiliation:
Mental Health Center North Zealand, Psychiatric Research Unit, Hilleroed, Denmark
M. Lunde
Affiliation:
Mental Health Center North Zealand, Psychiatric Research Unit, Hilleroed, Denmark
P. Bech
Affiliation:
Mental Health Center North Zealand, Psychatric Research Center, Hilleroed, Denmark

Abstract

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Introduction

Wake therapy (sleep deprivation) is known to induce a rapid amelioration of depressive symptoms. Recently, techniques using bright light therapy and sleep time control have been developed to sustain the acute response of wake therapy.

Objectives

The aim of this study was to establish the efficacy of these new methods and to control for the placebo response by incorporating an active control group.

Methods

Patients with an actual diagnosis of unipolar or bipolar major depression were randomized to either a wake group or an exercise group and followed for 9 weeks. All patient were treated with duloxetine 60 mg daily. After a one week medication run-in phase, all patient were admitted to an open ward for six days: The wake group had 3 wake nights during their stay in combination with daily bright light treatment and sleep time control and the exercise-group started their exercise program. Bright light and exercise were continued for the whole study period.

Results

Patients in the wake group had a statistically significant larger improvement from immediately after wake therapy and maintained for the rest of the study period. At end of study the Wake group achieved a response / remission rate of 70.2 % and 45.6 %. The exercise group had a response/remission rate of 42.2 % and 23.1 %

Conclusion

The chronotherapeutic intervention induced a rapid and sustained response superior to the response seen in the exercise group.

Type
S06-03
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 2031
Copyright
Copyright © European Psychiatric Association 2011
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