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Volumetric MRI analysis of hippocampal subregions in Cushing's disease: A model for glucocorticoid neural modulation

Published online by Cambridge University Press:  16 April 2020

T. Toffanin ,
F. Nifosì ,
H. Follador ,
A. Passamani ,
F. Zonta ,
G. Ferri ,
M. Scanarini ,
P. Amistà ,
G. Pigato  and
C. Scaroni
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T. Toffanin*
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
F. Nifosì
Affiliation:
Department of Mental Health, II Psychiatric Service, ULSS 20, Piazza L. Scuro no. 10, 37135Verona, Italy
H. Follador
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
A. Passamani
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
F. Zonta
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
G. Ferri
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
M. Scanarini
Affiliation:
Department of Neurosciences, Neurosurgery Unit, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
P. Amistà
Affiliation:
Department of Radiology, Neuroradiology Unit, Hospital of Rovigo, Viale Tre Martiri no. 140, 45100Rovigo, Italy
G. Pigato
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
C. Scaroni
Affiliation:
Department of Medical and Surgical Sciences, Division of Endocrinology, University-Hospital of Padova, Via Ospedale Civile no. 105, 35128Padova, Italy
F. Mantero
Affiliation:
Department of Medical and Surgical Sciences, Division of Endocrinology, University-Hospital of Padova, Via Ospedale Civile no. 105, 35128Padova, Italy
C. Carollo
Affiliation:
Department of Neurosciences, Neuroradiology Unit, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy
G.I. Perini
Affiliation:
Department of Neurosciences, Section of Psychiatry, University-Hospital of Padova, Via Giustiniani no. 2, 35128Padova, Italy Department of Psychiatry, ULSS 7, Pieve di Soligo (TV), Via Lubin no. 16, 31053 Pieve di Soligo (TV), Italy
*
*Corresponding author. Tel.: +3949/8213830; fax: +3949/8755574. E-mail address: [email protected] (T. Toffanin).
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Abstract

Several preclinical studies have demonstrated neuronal effects of glucocorticoids on the hippocampus (HC), a limbic structure with anterior–posterior anatomical and functional segmentation. We propose a volumetric magnetic resonance imaging analysis of hippocampus head (HH), body (HB) and tail (HT) using Cushing's disease (CD) as model, to investigate whether there is a differential sensitivity to glucocorticoid neuronal damage in these segments. We found a significant difference in the HH bilaterally after 12 months from trans-sphenoidal surgical selective resection of the adrenocorticotropic hormone (ACTH)-secreting pituitary micro-adenomas. This pre–post surgery difference could contribute to better understand the pathopysiology of CD as an in vivo model for stress-related hypercortisolemic neuropsychiatric disorders.

Keywords

Cushing's diseaseHippocampusMRIGlucocorticoidsTrans-sphenoidal micro-adenomas surgery
Type
Short communication
Information
European Psychiatry , Volume 26 , Issue 1 , January 2011 , pp. 64 - 67
Copyright
Copyright © Elsevier Masson SAS 2011

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