To study the influence of vital exhaustion (VE) on risk of an arterial hypertension (AH) in female population of 25-64 years in Russia over 16 years.

Within the WHO MONICA-psychosocial program (MOPSY) random representative sample of women aged 25-64 years (n=870) were surveyed in 1994 in Novosibirsk. VE were measured at the baseline by questionnaire 'MOPSY”. From 1995 to 2010 women were followed for incidence of AH.

High level of VE in studied cohort was revealed in 31.3 % of women. Hazard ratio (HR) of AH in women with VE during the first 5 years of study was higher in 2 time, compared women which had no VE (HR=1.99, 95.0%CI:1,03-3,87; p<0,05). There was a tendency of increasing risk of AH from younger to older age groups. HR of incident AH in persons with VE within 10 years after the baseline examination was 1.47 (p>0,05), but was significant in such age categories as 35-44 (HR=2.32, 95.0%CI:1,73-7,30; p<0,05) and 45-54 years (HR=2.34; 95%CI:1,94-5,84; p<0,05). We did not have significant risk of AH over 16 years of follow up in women with VE (HR=1.02; 95.0%CI: 0,23-4,62; p>0,05). AH more likely developed in physical workers with VE (p<0,05), and as tendency in married women with VE.

Our finding show high prevalence of HVE (33.4%) in female cohort of 25-64 years as a significant predictor of higher risk of AH over the long-term period, especially in married women occupied in manual work.