Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-22T18:06:03.540Z Has data issue: false hasContentIssue false
  • English
  • Français

Valpromide increases amplitude of heart rate circadian rhythm in remitted bipolar and unipolar disorders.A placebo-controlled study

Published online by Cambridge University Press:  16 April 2020

P Lemoine ,
J Fondarai  and
T Faivre
P Lemoine
Affiliation:
Unité Clinique de Psychiatrie Biologique, CH Le Vinatier, 95, Boulevard Pinel, 69677Lyon-Bron, France Centre de recherche Philippe Pinel, avenue Bourassa, Montreal, Quebec, Canada
J Fondarai
Affiliation:
Service de médecine du sport. Hôpital Salvator, Marseilles, France
T Faivre*
Affiliation:
Unité Clinique de Psychiatrie Biologique, CH Le Vinatier, 95, Boulevard Pinel, 69677Lyon-Bron, France
*
*Correspondence and reprints.
Get access

Extract

The aim of this study was to investigate for the effects of valpromide on heart rate circadian rhythm in remitted recurrent unipolar and bipolar disorders (DSM-III-R). It consisted of a comparative, randomized, double-blind, repeated cross-over study of valpromide versus placebo over four four-week periods. The primary evaluation criteria was heart rate (HR). Secondary criteria comprised motor activity (MA) and the Bech and Rafaelsen mania assessment scale, Horne and Ostberg questionnaire, Montgomery and Asberg depression rating scale, Spiegel questionnaire, a sleep diary, and Clinical Global Impression. Fifteen patients were included, giving 60 one-month periods (30 valpromide periods and 30 placebo periods).

Cosinor analysis of HR and MA data revealed a difference in amplitude (P = 0.037, analysis of variance, one-tailed test).

The clinical sleep study shows that the duration of sleep was greater with valpromide than with placebo (P = 0.007, one-tailed test). Similarly, evaluation of the quality of sleep by patients themselves showed valpromide to be superior to placebo (P = 0.045, one-tailed test). The results of analysis of the Spiegel questionnaire also confirm the superiority of valpromide over placebo. Safety and compliance were comparable for the active drug and the placebo.

In conclusion, the relatively small sample size requires cautious interpretation of this study. Nevertheless, these initial results show a definite effect of valpromide on a biological rhythm that leads one to suppose that it may be effective through a ‘synchronizing’ effect.

Keywords

circadian rhythmsheart rate rhythmunipolar, bipolarvalpromide, placebo
Type
Original article
Information
European Psychiatry , Volume 15 , Issue 7 , November 2000 , pp. 424 - 432
Copyright
Copyright © 2001 Éditions scientifiques et médicales Elsevier SAS. All rights reserved

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bech, PRafaelsen, OJKram, PPBolwig, TGThe mania rating scale. Scale construction and inter-observer agreement Neuropharmacol 1978; 17: 430–431CrossRefGoogle ScholarPubMed
Beersma, DGVan Den Hoofdakker, RHBerkestijn, HBody temperature and sleep physiology in endogenous depressivesMendlewicz, JVan Praag, HMAdvances in biological Psychiatry 1983 Krager Basel114–127Google Scholar
Boorsook, DRichardson, GSMoore Ede, MCBrennan, M.J.WGABA and circadian timekeeping. Implication for manic depression and sleep disorders Med Hypothesis 1986; 2: 185–198CrossRefGoogle Scholar
D'Mello, DAMcNeil, JAMsibi, BSeasons and bipolar disorder Ann Clin Psychiatry 1995; 1: 11–18CrossRefGoogle Scholar
Duncan, WCWehr, TAPharmacological and non-pharmacological chronotherapies of depression Ann Rev Chronopharmacol 1988; 4: 137–170Google Scholar
Englelmann, WPflug, BKlemke, WJohnsson, ALithium-induced change of internal phase relationship of circadian rhythms in humans and other observationsWehr, TAGoodwin, EKCircadian rhythms in psychiatry 1983 The Boxwood Press New York89–107Google Scholar
Guyatt, HThe n of one randomized controlled trial: clinical usefulness. Our three-year experience Ann Intern M vol 1990 293–299CrossRefGoogle Scholar
Horne, JAOstberg, OA self-assessment questionnaire to determine morningness-eveningness in circadien rhythms Int J Chronobiol 1976; 4: 97–110Google Scholar
Kendall, MGStuart, AThe advanced theory of statistics 1966 Charles Griffin & Co Ltd LondonGoogle Scholar
Klemfuss, HKripke, DFAntimanic drug stabilizes hamster circadian rhythms Psychiatry Res 1995; 3: 215–222CrossRefGoogle Scholar
Lambert, PA. Acute and prophylactic therapies of patients with affective disorders using dipropylacetamide or valpromide. VIIth World Congress of Psychiatry. Vienna, 11-16 July 1983Google Scholar
Lemoine, PBiological rhythms, anxiety, cognition and sleep Psychiatr Psychobiol 1988; 3: 59–64Google Scholar
Lemoine, PLa femme et la dépression, aspects chronobiologiques Neuro-Psy 1993; 8: 263–270Google Scholar
Lozano, FFrançois, TSechter, DChronobiologie et dépression: données récentes Inform Psychiatr 1993; 4: 369–376Google Scholar
Monk, TLeng, VFolkard, SWeitzman, ECircadian rhythms in subjective alertness and core body temperature Chronobiologia 1983; 11: 343–354Google Scholar
Montgomery, SAAsberg, MA new depression scale designed to be sensitive to change Br J Psychiatry 1979; 134: 382–389CrossRefGoogle ScholarPubMed
NIMH Biological rhythms in psychiatry and medicine 1970 US Department of Health, Education and Welfare Washington, DCGoogle Scholar
Parry, BMendelson, WDuncan, WCSack, DWehr, TALongitudinal sleep EEG, temperature and activity measurements across the menstrual cycle in patients with premenstrual depression and in age-matched controls Psychiatry Res 1989; 30: 285–303CrossRefGoogle ScholarPubMed
Pflug, BTolle, RDisturbance of the 24-hour rhythms in endogenous depression and the treatment of endogenous depression by sleep deprivation Pharmacopsychiatry 1971; 6: 187–196CrossRefGoogle Scholar
Reinberg, AAndlauder, PTeinturier, PDe Prins, JMalbecq, WDupont, JDésynchronisation du rythme circadien de la température orale des hommes jeunes tolérant mal le travail de nuit CR Acad Sci Paris 1983; 296: 267–270Google Scholar
Rosenthal, NELevendoski, ASkwerer, RJoseph-Vanderpool, JRKelly, KAHardin, T et al. Effects of light treatment on core body temperature in seasonal affective disorder Biol Psychiatry 1990; 27: 39–50CrossRefGoogle ScholarPubMed
Ruk, BNeural mechanisms for entrainment and generation of mammalian circadian rhythms Fed Proc 1979; 38: 2589–2895Google Scholar
Sack, DARosenthal, NEParry, BLWehr, TABiological rhythms in psychiatryMelzer, HEPsychopharmacology: the third generation of progress 1987 Raven Press New York669–685Google Scholar
Sechter, DPoirel, CChronobiologie et psychiatrie, rapport de psychiatrieCongrès de Psychiatrie et de Neurologie de Langue Française 1985 Masson ParisGoogle Scholar
Severino, SWagner, RMoline, MHurt, SPollak, CZendell, SHigh nocturnal body temperature in premenstrual syndrome and late luteal phase dysphoric disorder Am J Psychiatry 1991; 10: 1329–1335Google Scholar
Song Jian, GShigehiro, ONobuya, OChronopharmacokinetics of valproic acid following constant rate administration in mice and influence of feeding schedule Zhongguo yaoli xuebao 1995; 16: 113–117Google Scholar
Souètre, EPringuey, DSalvati, ERobert, PDarcourt, GRythmes circadiens de la température centrale et de la cortisolémie dans la dépression Encéphale 1985; 11: 185–198Google Scholar
Souètre, ESalavati, EDarcourt, GLe concept de rythme biologique en psychopathologie Rev EEG Neurophysiol Clin 1987; 17: 359–376Google Scholar
Spiegel, RSleep and sleeplessness in advanced ageWeitzman, EDAdvances in sleep research 1981 Spectrum Publications Jamaica000–000Google Scholar
Suter, EMarti, BTschopp, AWanner, HUEffekte von Jogging auf psychisches Befinden und saisonale Stimmungs-Schwankungen: eine randomisierte Studie mit gesunden Frauen und Männern Schweiz Med Wochenschr 1991; 121: 1254–1263Google Scholar
Taillard, JSanchez, PLemoine, PMouret, JHeart rate circadian rhythm as a biological marker of desynchronization in major depression: a methodological and preliminary report Chronobiol Int 1990; 7: 305–316CrossRefGoogle ScholarPubMed
Taillard, JLemoine, PBoule, PDrogue, MMouret, JSleep and heart rate circadian rhythms in depression: the necessity to separate Chronobiol Int 1993; 10: 63–72CrossRefGoogle Scholar
Tsujimoto, TYamada, NShimoda, KHanada, KTakahashi, SCircadian rhythms in depression. Part II: circadian rhythms in inpatients with various mental disorders J Affect Disord 1990; 18: 199–210CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.