Hostname: page-component-848d4c4894-2xdlg Total loading time: 0 Render date: 2024-07-05T21:31:13.911Z Has data issue: false hasContentIssue false

Tricyclics and malignant syndrome

Published online by Cambridge University Press:  16 April 2020

M Abbar
Affiliation:
Service de Psychologie Médicale, Hôpital Lapeyronie, 34059 Montpellier
B Carlander*
Affiliation:
Service de Neurologie B, Hôpital Gui-de-Chauliac, 34059 Montpellier, France
D Castelnau
Affiliation:
Service de Psychologie Médicale, Hôpital Lapeyronie, 34059 Montpellier
*
*Correspondence and reprints.
Get access

Summary

A clinical and biological pattern similar to that of neuroleptic malignant syndrome is reported in a depressed patient treated with trimipramine, without any concomitant use of neuroleptics. The antidopaminergic properties of this drug, one of the tricyclic antidepressants, may account for this uncommon side effect.

Type
Case report
Copyright
Copyright © Elsevier, Paris 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baca, L, Martinelli, LNeuroleptic malignant syndrome: a unique association with a tricyclic antidepressant Neurology 40 1990 17971798CrossRefGoogle ScholarPubMed
Caroff, SN, Mann, SCNeuroleptic malignant syndrome Med Clin N Am 77 1993 185202CrossRefGoogle ScholarPubMed
Corrigan, FM, Coulter, FNeuroleptic malignant syndrome, amitriptyline and thioridazine Biol Psychiatry 23 1988 317323CrossRefGoogle ScholarPubMed
Domingo, P, Munoz, J, Bonastre, Met alBenign type of malignant syndrome Lancet i 1989 50Google Scholar
Fornazzari, L, Ichise, M, Remington, G, Smith, IRabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings J Psychiatr Neurosci 16 1991 227279Google ScholarPubMed
Gastpar, MClinical originality and new biology of trimipramine Drugs 38suppl 11989 4348CrossRefGoogle ScholarPubMed
Grant, RNeuroleptic malignant syndrome Br Med J 288 1984 1690CrossRefGoogle Scholar
Halaris, AE, Belendiuk, KT, Freedman, DXAntidepressant drugs affect dopamine uptake Biochem Pharmacol 24 1975 18961898CrossRefGoogle ScholarPubMed
Halman, M, Goldbloom, DSFluoxetine and neuroleptic malignant syndrome Biol Psychiatry 28 1990 518521CrossRefGoogle ScholarPubMed
Karobath, METricyclic antidepressants drugs and dopamine sensitive adenylate cyclase from rat brain striatum Eur J Pharmacol 30 1975 159163CrossRefGoogle ScholarPubMed
Kline, SS, Slack, Mauro L, Scala-Barnett, DM, Zick, DSerotonin syndrome versus neuroleptic malignant syndrome as a cause of death Clin Pharm 8 1989 510514Google ScholarPubMed
Langlow, JR, Alarcon, RDTrimipramine-induced neuroleptic malignant syndrome after transient psychogenic polydipsia in one patient J Clin Psychiatry 50 1989 144145Google ScholarPubMed
Lapierre, YDA review of trimipramine — 30 years of clinical use Drugs 38suppl 11989 1724CrossRefGoogle ScholarPubMed
Lejoyeux, M, Fineyre, F, Adès, JThe serotonin syndrome Am J Psychiatry 149 1992 1410Google ScholarPubMed
Lejoyeux, M, Rouillon, F, Adès, J, Gorwood, PNeural symptoms induced by tricyclic antidepressants: phenomenology and pathophysiology Acta Psychiatr Scand 85 1992 249256CrossRefGoogle ScholarPubMed
Levenson, JNeuroleptic malignant syndrome Am J Psychiatry 142 1985 11371145Google ScholarPubMed
Madakasira, SAmoxapine-induced neuroleptic malignant syndrome DICP 23 1989 5055CrossRefGoogle ScholarPubMed
Potter, WZ, Rudorfer, MV, Manji, HThe pharmacologic treatment of depression New Engl J Med 325 1991 633642Google ScholarPubMed
Rosebush, P, Stewart, TA prospective analysis of 24 episodes of neuroleptic malignant syndrome Am J Psychiatry 146 1989 717725Google ScholarPubMed
Schibuk, M, Schachter, DA role for catecholamines in the pathogenesis of neuroleptic malignant syndrome Can J Psychiatry 31 1986 6669CrossRefGoogle ScholarPubMed
Sternbach, HThe serotonin syndrome Am J Psychiatry 148 1991 705713Google ScholarPubMed
Taylor, NE, Schwartz, HINeuroleptic malignant syndrome following amoxapine overdose J Nerv Ment Dis 176 1988 249251CrossRefGoogle ScholarPubMed
Wils, VExtrapyramidal symptoms in a patient treated with fluvoxamine J Neurol Neurosurg Psychiatry 55 1992 330331CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.