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Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the opus trial. A randomized clinical trial of integrated treatment and standard treatment

Published online by Cambridge University Press:  16 April 2020

M. Nordentoft ,
P. Jeppesen ,
L. Petersen ,
A. Thorup ,
J. Øhlenschlæger ,
T. Christensen ,
G. Krarup  and
P. Jørgensen
M. Nordentoft
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
P. Jeppesen
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
L. Petersen
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
A. Thorup
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
J. Øhlenschlæger
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
T. Christensen
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
G. Krarup
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
P. Jørgensen
Affiliation:
Department of Psychiatry, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark

Abstract

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Background:

Only a few randomized clinical trials have tested the effect on transition rates of intervention programs for patients with sub-threshold psychosis-like symptoms.

Aim:

To examine whether integrated treatment reduced transition to psychosis for first-contact patients diagnosed with schizotypal disorder.

Methods:

Seventy-nine patients were randomized to integrated treatment or standard treatment. Survival analysis with multivariate Cox-regression was used to identify factors determinant for transition to psychotic disorder.

Results:

In the multivariate model, male gender increased risk for transition to psychotic disorder (relative risk = 4.47, (confidence interval 1.30-15.33)), while integrated treatment reduced the risk (relative risk = 0.36 (confidence interval 0.16-0.85)). At two-year follow-up, the proportion diagnosed with a psychotic disorder was 25.0 percent for patients randomized to integrated treatment compared to 48.3 percent for patients randomized to standard treatment.

Conclusion:

Integrated treatment postponed or inhibited onset of psychosis in significantly more cases than standard treatment.

Type
Poster Session 1: Schizophrenia and Other Psychosis
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S129
Copyright
Copyright © European Psychiatric Association 2007
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