Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-23T16:39:24.705Z Has data issue: false hasContentIssue false
  • English
  • Français

The thyrotropin-releasing hormone test: some statistical considerations

Published online by Cambridge University Press:  16 April 2020

CA de Mendonca Lima ,
S Vandel  and
P Bizouard
CA de Mendonca Lima
Affiliation:
Service Psycho-Social, 18, rue de l'Hôtel de Ville, 1920Martigny, Switzerland
S Vandel
Affiliation:
Centre Hospitalier Universitaire de Besançon, 25000Besançon, France
P Bizouard
Affiliation:
Centre Hospitalier Universitaire de Besançon, 25000Besançon, France
Get access

Summary

Final conclusions and data comparisons from the thyrotropin-releasing hormone (TRH) test results are made difficult by differences in test implementation methods, ie, TRH different administration routes, dosages and blood sampling times. A number of statistical analyses are feasible, which may also influence test interpretation. The authors review some types of statistical analyses and suggest using the area under curve (AUC) method as a means of evaluation. The TRH test was performed before treatment and after a 5-day wash-out period, in 40 depressed patients hospitalized in the Psychiatric Unit of Besancon Teaching Hospital (Centre Hospitalier Universitaire de Besançon). Variation analyses performed by peak and threshold comparison (7.0 IµU/ml) and by the AUC method (386 IµU/ml) in positive and negative patients revealed some statistical differences.

Keywords

depressionTRH test
Type
Short communication
Information
European Psychiatry , Volume 7 , Issue 1 , 1992 , pp. 39 - 42
Copyright
Copyright © Elsevier, Paris 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) DSM-III: Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, American Psychiatric Association, Washington, DCGoogle Scholar
Asberg, MMontgomery, SAPerris, CSchalling, DSedvall, G (1978) A Comprehensive Psychopathological rating scale Acta Psychiat Scand suppl 271, 5–27CrossRefGoogle Scholar
Baumgartner, AHahnenkamp, LMeinhold, H (1985) Effects of age and diagnosis on thyrotropin response to thyrotropin-releasing hormone in psychiatric patients Psychiatry Res 17, 285–294CrossRefGoogle Scholar
Extein, IPottasch, ALCGold, MS (1981) The thyrotropinreleasing hormone test in the diagnosis of unipolar depression Psychiatry Res 5, 311–316CrossRefGoogle Scholar
Extein, IPottasch, ALCGold, MSSilver, JM (1982) Thyroid-stimulating hormone response to thyrotropinreleasing hormone in unipolar depression before and after clinical improvement Psychiatry Res 6, 161–169CrossRefGoogle Scholar
Gold, MSPottasch, ALCExtein, IMartin, DMHoward, EMueller, EASweeney, DR (1981) The TRH test in the diagnosis of major and minor depression Psychoneuroendocrinology 6, 159–169CrossRefGoogle Scholar
Kirkegaard, C (1981) The thyrotropin response to thyrotropin-releasing hormone in endogeneous depression Psychoneuroendocrinology 6, 189–212CrossRefGoogle Scholar
Kirkegaard, CBjorum, NCohn, DLauridsen, UB (1978) thyrotropin-releasing hormone stimulation test in manic-depressive illness Arch Gen Psychiatry 35, 1017–1021CrossRefGoogle ScholarPubMed
Loosen, PTPrange, AJ (1982) Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review Am J Psychiatry 139, 405–416Google ScholarPubMed
Loosen, PTMason, GAPrange, J (1982) The TRH test in normal subjects: methodological considerations Psychoneuroendocrinology 7, 147–153CrossRefGoogle ScholarPubMed
Loosen, PT (1986) Hormones of hypothalamic-pituitarythyroid axis: a psychoneuroendocrine perspective Pharmacopsychiatry 19, 401–415CrossRefGoogle Scholar
Maes, MHobin, PDe Ruyter, MSuy, E (1988) The thyrotropin-releasing hormone test in depressed and non depressed psychiatric patients Psychiatry & Psychobiol 3, 373–379Google Scholar
Masturzo, PTosca, PMurialdo, G (1988) Thyrotropin and prolactin response to different doses of thyrotropin-releasing hormone in depression Neuropsychobiology 20, 120–125CrossRefGoogle Scholar
Roth, MGurney, CMountjoy, CP (1983) The Newcastle rating scale Acta Psychiatr Scand suppl 310, 42–54CrossRefGoogle Scholar
Schäfgen, WGrebe, SFSchatz, H (1983) Pernasal versus intravenous administration of TRH: effects on thyrotropin, prolactin, triiodothyronine, thyroxine and thyroglobuline in healthy subjects Horm Metab Res 15, 52–53CrossRefGoogle ScholarPubMed
Schelesser, MARush, AJFairchild, CCrowley, GOrsulak, P (1983) The thyrotropin-releasing hormone stimulating test: a methodological study Psychiatry Res 9, 59–67CrossRefGoogle Scholar
Staub, JJGirard, JMueller-Brand, J (1978) Blunting of TSH response after repeated oral administration of TRH in normal and hypothyroid subjects J Clin Endocrinol & Metab 46, 260–266CrossRefGoogle ScholarPubMed
Staub, JJRyff-Deleche, ASPaul, S (1985) Intranasal thyrotropin releasing hormone is a potent stimulus for TSH release in man (comparison with intravenous and oral TRH) Clin Endocrinol 22, 567–572CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.