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Thyrotropin and prolactin responses to TRH in delusional (psychotic) and nondelusional depressed patients

Published online by Cambridge University Press:  16 April 2020

L Lykouras ,
M Markianos ,
Y Papakostas  and
D Malliaras
L Lykouras
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
M Markianos
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
Y Papakostas
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
D Malliaras
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
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Summary

The thyrotropin (TSH) and prolactin (PRL) responses to protirelin (TRH) were studied in 62 female unipolar depressive patients, 24 delusional (psychotic) and 38 nondelusional (Diagnostic and Statistical Manual [DSM]-III-R criteria). The TSH response to TRH was blunted (≤6 μlU/mL) in ten of the 24 delusional (41.6%) and in 18 of the 38 nondelusional (47.4%) patients, the difference being not significant. The TSH and PRL responses to TRH, calculated as area under the curve, were not different between the two groups. Similar results were obtained when the response patterns were compared by repeated measure analysis of covariance.

Keywords

TRH testTSHprolactindelusiondepression
Type
Original articles
Information
European Psychiatry , Volume 12 , Issue 5 , 1997 , pp. 259 - 262
Copyright
Copyright © European Psychiatric Association 1997

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