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Substance Use and Physical Health in Patients with Bipolar Disorder Under Maintenance Treatment

Published online by Cambridge University Press:  16 April 2020

M.P. Garcia-Portilla ,
P.A. Saiz ,
G. Florez ,
M.T. Bascaran ,
S. Al-Halabi ,
M. Bousoño  and
J. Bobes
M.P. Garcia-Portilla
Affiliation:
Department of Psychiatry, University of Oviedo Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM, Oviedo
P.A. Saiz
Affiliation:
Department of Psychiatry, University of Oviedo Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM, Oviedo
G. Florez
Affiliation:
U.T.C.A., SERGAS, Orense, Spain
M.T. Bascaran
Affiliation:
Department of Psychiatry, University of Oviedo Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM, Oviedo
S. Al-Halabi
Affiliation:
Department of Psychiatry, University of Oviedo Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM, Oviedo
M. Bousoño
Affiliation:
Department of Psychiatry, University of Oviedo Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM, Oviedo
J. Bobes
Affiliation:
Department of Psychiatry, University of Oviedo Instituto de Salud Carlos III, Centro de Investigación en Red de Salud Mental, CIBERSAM, Oviedo

Abstract

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Background:

To date, little is known about the impact of substance use on physical health of patients with bipolar disorder. This study provides data on the impact of tobacco, alcohol and cannabis upon weight, metabolic profile and cardiovascular risk in these patients.

Methods:

Naturalistic, cross-sectional, multicenter study conducted in Spain. Current use of tobacco, alcohol and cannabis was registered based on patient’ self-reports. Patients were evaluated for presence of metabolic syndrome (MetS) according to modified NCEP ATP III criteria, for cardiovascular risk using the Framinghan function (CHD) and the Systematic COronary Risk Evaluation (SCORE) function (CMR).

Results:

The mean age was 46.6 years and 49% were male. Fitty-one percent used tobacco, 13% alcohol and 12.5% cannabis. Mean body mass index (BMI) was 27.9 kg/m2, 22.4% had MetS and ten-year CHD and CMR risks were 7.6% and 1.8% respectively. Patients who used tobacco had significantly higher CHD risk (8.82 versus 5.74, p < 0.01), and used more antipsychotic (1.23 versus 1.04, p 0.002) and overall (3.18 versus 2.71, p 0.01) drugs for the treatment of their bipolar disorder. Patients who used cannabis had significantly lower BMI (26.0 versus 28.2, p < 0.05) and lower CMR (0.37 versus 1.99, p < 0.001), however, when controlling by age, severity of mania and presence of metabolic syndrome these associations disappear.

Conclusions:

Substance use, mainly tobacco, is high in patients with bipolar disorder. Use of tobacco is associated with higher cardiovascular risk and greater number of antipsychotic and overall drugs for the bipolar disorder.

Type
P01-189
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E577
Copyright
Copyright © European Psychiatric Association 2009
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