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Subjective quality of life and its changes in patients at-risk for psychosis results of the EPOS study

Published online by Cambridge University Press:  16 April 2020

R. Salokangas ,
T. Svirskis ,
M. Heinimaa ,
J. Klosterkötter ,
S. Ruhrmann ,
H. Graf von Reventlow ,
D. Linszen ,
P. Dingemans ,
M. Birchwood  and
P. Patterson
R. Salokangas
Affiliation:
Department of Psychiatry, University of Turku, Turku, Finland
T. Svirskis
Affiliation:
Department of Psychiatry, University of Helsinki, Helsinki, Finland
M. Heinimaa
Affiliation:
Department of Psychiatry, Univerisity of Turku, Turku, Finland
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
H. Graf von Reventlow
Affiliation:
LWL-Universitaetsklinik Bochum, Ruhr-Universität Bochum, Bochum, Germany
D. Linszen
Affiliation:
Acadmic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
P. Dingemans
Affiliation:
Acadmic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
M. Birchwood
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK
P. Patterson
Affiliation:
Early Intervention Service, University of Birmingham, Birmingham, UK

Abstract

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Objectives

In the European Prediction of Psychosis Study (EPOS) a large sample of young patients at high risk of psychosis (HR) were examined and their conversion rate to psychosis during 18 months follow-up was estimated. This presentation describes quality of life (QoL) and its changes in patients at risk of psychosis who did or did not convert to psychosis.

Methods

In all, 245 young HR patients were recruited and followed for 9 and 18 months. Risk of psychosis was defined by occurrence of basic symptoms (BS), attenuated psychotic symptoms (ATP), brief, limited or intermittent psychotic symptoms (BLIPS) or familial risk plus reduced functioning (FR-RF). QoL was assessed at baseline and at 9 and 18 months’ follow-ups, and analysed in the HR-patients who converted (HR-P; n = 40) or did not converted to psychosis (HR-NP; n = 205).

Results

There were no differences in the course of QoL between the HR-P and HR-NP patients. Of the inclusion criteria, only BS associated with poor QoL at baseline. Among HR-NP subjects, depressive symptoms associated with QoL at baseline and predicted poor QoL at 9 and 18 month follow-ups.

Conclusions

QoL of the HR-NP patients is as poor as that of the HR-P. From the QoL point of view, all HR patients require intensive treatment intervention from the first contact on. Especially, depressive disorders need to be treated vigorously.

Type
S08-03
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 2039
Copyright
Copyright © European Psychiatric Association 2011
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