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Sleep disturbances in bipolar disorder with comorbid post-traumatic stress disorder

Published online by Cambridge University Press:  19 July 2023

F. Cruz Sanabria ,
C. Bonelli ,
D. Gravina ,
M. Violi ,
L. Massoni ,
S. Bruno ,
U. Faraguna ,
L. Dell’Osso  and
C. Carmassi
F. Cruz Sanabria*
Affiliation:
1Department of Translational Research and of New Surgical and Medical Technologies
C. Bonelli
Affiliation:
2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
D. Gravina
Affiliation:
2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
M. Violi
Affiliation:
2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
L. Massoni
Affiliation:
2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
S. Bruno
Affiliation:
1Department of Translational Research and of New Surgical and Medical Technologies
U. Faraguna
Affiliation:
1Department of Translational Research and of New Surgical and Medical Technologies
L. Dell’Osso
Affiliation:
1Department of Translational Research and of New Surgical and Medical Technologies 2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
C. Carmassi
Affiliation:
1Department of Translational Research and of New Surgical and Medical Technologies 2Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
*
*Corresponding author.

Abstract

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Introduction

Sleep disturbances are frequently reported in patients with Bipolar Disorder (BD), parallel, patients with BD report significantly higher rates of exposure to major lifetime traumatic events than the general population with a high risk of developing PTSD.

Objectives

The aim of this study was to compare sleep parameters subjectively and objectively measured, in patients with BD with or without PTSD with respect to healthy control subjects.

Methods

73 patients with BD (26 BD+ PTSD and 46 BDw/oPTSD) and 88 HC were evaluated through actigraphic monitoring to explore sleep and circadian parameters, scales exploring sleep quality (Pittsburgh Sleep Quality Index -PSQI-) and chronotype (reduced Morningness-Eveningness Questionnaire –rMEQ-) and the Trauma and Loss Spectrum Self Report (TALS-SR), for lifetime trauma and loss spectrum symptoms.

Results

Compared to age-matched HC, patients with BD reported lower sleep quality, lower rMEQ scores suggestive of delayed chronotype, longer total sleep time, higher waking after sleep onset, lower interdaily stability and lower sleep health. Patients with BD+PTSD reported significantly higher PSQI scores than BDw/oPTSD; significant correlations between the PSQI total scores and TALS-SR symptomatic domains emerged in the BD+PTSD group only.

Conclusions

Our results suggest a strong correlation between sleep disturbances, particularly evaluated by subjective measures, and PTSD symptoms in patients with BD.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S196 - S197
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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