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Short-term functional outcome and premorbid adjustment in clinical high-risk patients. Results of the EPOS project

Published online by Cambridge University Press:  15 April 2020

R.K.R. Salokangas ,
M. Heinimaa ,
T. From ,
E. Löyttyniemi ,
T. Ilonen ,
S. Luutonen ,
J. Hietala ,
T. Svirskis ,
H.G. von Reventlow  and
G. Juckel
...Show all authors
R.K.R. Salokangas*
Affiliation:
Department of Psychiatry, University of Turku 70, Kunnallissairaalantie, 20700Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finland Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland
M. Heinimaa
Affiliation:
Department of Psychiatry, University of Turku 70, Kunnallissairaalantie, 20700Turku, Finland
T. From
Affiliation:
Department of Psychiatry, University of Turku 70, Kunnallissairaalantie, 20700Turku, Finland
E. Löyttyniemi
Affiliation:
Department of Biostatistics, University of Turku, Turku, Finland
T. Ilonen
Affiliation:
Department of Psychiatry, University of Turku 70, Kunnallissairaalantie, 20700Turku, Finland
S. Luutonen
Affiliation:
Department of Psychiatry, University of Turku 70, Kunnallissairaalantie, 20700Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finland
J. Hietala
Affiliation:
Department of Psychiatry, University of Turku 70, Kunnallissairaalantie, 20700Turku, Finland Psychiatric Clinic, Turku University Central Hospital, Turku, Finland Turku Psychiatric Clinic, Turku Mental Health Centre, Turku, Finland
T. Svirskis
Affiliation:
Department of Psychiatry, University of Helsinki, Helsinki, Finland Peijas Hospital, Helsinki University Central Hospital, Helsinki, Finland
H.G. von Reventlow
Affiliation:
Department of Psychiatry, Ruhr-University Bochum, LWL University Hospital, Bochum, Germany
G. Juckel
Affiliation:
Department of Psychiatry, Ruhr-University Bochum, LWL University Hospital, Bochum, Germany
D. Linszen
Affiliation:
Department of Psychiatry and Psychology, University of Maastricht, Maastricht, Netherlands
P. Dingemans
Affiliation:
Mediant, Enschede, Netherlands
M. Birchwood
Affiliation:
School of Psychology, University of Birmingham, Birmingham, United Kingdom
P. Patterson
Affiliation:
Youthspace – Birmingham & Solihull Mental Health Foundation Trust, Birmingham, United Kingdom
F. Schultze-Lutter
Affiliation:
University Hospital of Child and Adolescent Psychiatry, University of Bern, Bern, Switzerland
S. Ruhrmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
J. Klosterkötter
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
*
*Corresponding author. E-mail address:[email protected] (R.K.R. Salokangas).
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Abstract

Purpose

In patients with schizophrenia, premorbid psychosocial adjustment is an important predictor of functional outcome. We studied functional outcome in young clinical high-risk (CHR) patients and how this was predicted by their childhood to adolescence premorbid adjustment.

Methods

In all, 245 young help-seeking CHR patients were assessed with the Premorbid Adjustment Scale, the Structured Interview for Prodromal Syndromes (SIPS) and the Schizophrenia Proneness Instrument (SPI-A). The SIPS assesses positive, negative, disorganised, general symptoms, and the Global Assessment of Functioning (GAF), the SPI-A self-experienced basic symptoms; they were carried out at baseline, at 9-month and 18-month follow-up. Transitions to psychosis were identified. In the hierarchical linear model, associations between premorbid adjustment, background data, symptoms, transitions to psychosis and GAF scores were analysed.

Results

During the 18-month follow-up, GAF scores improved significantly, and the proportion of patients with poor functioning decreased from 74% to 37%. Poor premorbid adjustment, single marital status, poor work status, and symptoms were associated with low baseline GAF scores. Low GAF scores were predicted by poor premorbid adjustment, negative, positive and basic symptoms, and poor baseline work status. The association between premorbid adjustment and follow-up GAF scores remained significant, even when baseline GAF and transition to psychosis were included in the model.

Conclusion

A great majority of help-seeking CHR patients suffer from deficits in their functioning. In CHR patients, premorbid psychosocial adjustment, baseline positive, negative, basic symptoms and poor working/schooling situation predict poor short-term functional outcome. These aspects should be taken into account when acute intervention and long-term rehabilitation for improving outcome in CHR patients are carried out.

Keywords

Premorbid adjustmentClinical high riskFunctional outcome
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 6 , August 2014 , pp. 371 - 380
Copyright
Copyright © Elsevier Masson SAS 2014

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References

Addington, J., Addington, D.Patterns of premorbid functioning in first episode psychosis: relationship to 2-year outcome. Acta Psychiatr Scand 2005;112:40–46.CrossRefGoogle ScholarPubMed
Addington, J., van Mastrigt, S., Addington, D.Patterns of premorbid functioning in first-episode psychosis: initial presentation. Schizophr Res 2003;62:23–30.CrossRefGoogle ScholarPubMed
Addington, J., Penn, D., Woods, S.W., Addington, D., Perkins, D.O.Social functioning in individuals at clinical high risk for psychosis. Schizophr Res 2008;99:119–124.CrossRefGoogle ScholarPubMed
Affleck, J.W., Burns, J., Forrest, A.D.Long-term follow-up of schizophrenic patients in Edinburgh. Acta Psychiat Scand 1976;53:227–237.CrossRefGoogle ScholarPubMed
Agerbo, E., Byrne, M., Eaton, W.W., Mortensen, P.B.Marital and labor market status in the long run in schizophrenia. Arch Gen Psychiatry 2004;61:28–33.CrossRefGoogle Scholar
Alanen, Y.O., Räkköläinen, V., Laakso, J., Rasimus, R., Kaljonen, A.Towards need-specific treatment of schizophrenic psychoses. Heidelberg: Springer-Verlag; 1986.CrossRefGoogle ScholarPubMed
Álvarez-Jiménez, M., Gleeson, J.F., Henry, L.P., Harrigan, S.M., Harris, M.G., Killackey, E.et al.Road to full recovery: longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years. Psychol Med 2012;42:595–606.CrossRefGoogle ScholarPubMed
Amminger, G.P., Resch, F., Mutschlechner, R., Friedrich, M.H., Ernst, E.Premorbid adjustment and remission of positive symptoms in first-episode psychosis. Eur Child Adolesc Psychiatry 1997;6:212–218.CrossRefGoogle ScholarPubMed
Amminger, G.P., Schafer, M.R., Papageorgiou, K., Klier, C.M., Cotton, S.M., Harrigan, S.M.et al.Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatr 2010;67:146–154.CrossRefGoogle ScholarPubMed
Andreasen, N.C., Olsen, S.Negative v positive schizophrenia. Definition and validation. Arch Gen Psychiatry 1982;39:789–794.CrossRefGoogle Scholar
Angermeyer, M.C., Goldstein, J.M., Kühn, L.Gender differences in schizophrenia: rehospitalization and community survival. Psychol Med 1989;19:365–382.CrossRefGoogle ScholarPubMed
Angermeyer, M.C., Kühn, L., Goldstein, J.M.Gender and the course of schizophrenia: differences in treated outcomes. Schizophr Bull 1990;16:293–307.CrossRefGoogle ScholarPubMed
Astrup, C., Noreik, K.Functional psychoses. Diagnostic and prognostic models. Springfield: Charles C Thomas; 1966.Google ScholarPubMed
Bae, S.W., Brekke, J.S., Bola, J.R.Ethnicity and treatment outcome variation in schizophrenia: a longitudinal study of community-based psychosocial rehabilitation interventions. J Nerv Ment Dis 2004;192:623–628.CrossRefGoogle ScholarPubMed
Bechdolf, A., Wagner, M., Ruhrmann, S., Harrigan, S., Putzfeld, V., Pukrop, R.et al.Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry 2012;20:22–29.CrossRefGoogle Scholar
Beiser, M., Bean, G., Erickson, D., Zhang, J., Iacono, W.G., Rector, N.A.Biological and psychosocial predictors of job performance following a first episode of psychosis. Am J Psychiatry 1994;151:857–863.Google ScholarPubMed
Birchwood, M., Todd, P., Jackson, C.Early intervention in psychosis. The critical period hypothesis. Review. Br J Psychiatry Suppl 1998;172:53–59.CrossRefGoogle Scholar
Bland, R.C., Orn, H.14-year outcome in early schizophrenia. Acta Psychiat Scand 1978;58:327–338.CrossRefGoogle ScholarPubMed
Bond, G.R.Principles of the individual placement and support model: empirical support. Psychiatr Rehabil J 1998;22:11–23.CrossRefGoogle Scholar
Brill, N., Reichenberg, A., Rabinowitz, J.et al.Accuracy of self-reported premorbid functioning in schizophrenia. Schizophr Res 2007;97:103–108.CrossRefGoogle Scholar
Bromet, E., Harrow, M., Kasl, S.Premorbid functioning and outcome in schizophrenics and nonschizophrenics. Arch Gen Psychiatry 1974;30:203–207.CrossRefGoogle ScholarPubMed
Browne, S., Roe, M., Lane, A., Gervin, M., Morris, M., Kinsella, A.et al.Quality of life in schizophrenia: relationship to sociodemographic factors, symptomatology and tardive dyskinesia. Acta Psychiat Scand 1996;94:118–124.CrossRefGoogle ScholarPubMed
Cannon, T.D., Cadenhead, K., Cornblatt, B., Woods, S.W., Addington, J., Walker, E.et al.Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch Gen Psychiatry 2008;65:28–37.CrossRefGoogle ScholarPubMed
Cannon-Spoor, H.E., Potkin, S.G., Wyatt, R.J.Measurement of premorbid adjustment in chronic schizophrenia. Schizophr Bull 1982;8:470–484.CrossRefGoogle ScholarPubMed
Carpenter, W.T. Jr., Heinrichs, D.W., Wagman, A.M.Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry 1988;145:578–583.Google ScholarPubMed
Castle, D.J., Wessely, S., Murray, R.M.Sex and schizophrenia: effects of diagnostic stringency, and associations with and premorbid variables. Br J Psychiatry 1993;162:658–664.CrossRefGoogle ScholarPubMed
Cook, J.A., Razzano, L.Vocational rehabilitation for persons with schizophrenia: recent research and implications for practice. Schizophr Bull 2000;26:87–103.CrossRefGoogle ScholarPubMed
Cooper, B.Schizophrenia, social class and immigrant status: the epidemiological evidence. Epidemiol Psichiatr Soc 2005;14:137–144.CrossRefGoogle ScholarPubMed
Craig, T.K., Garety, P., Power, P., Rahaman, N., Colbert, S., Fornells-Ambrojo, M.et al.The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis. BMJ 2004;329:1067.CrossRefGoogle ScholarPubMed
Deary, I.J., Johnson, W.Intelligence and education: causal perceptions drive analytic processes and therefore conclusions. Int J Epidem 2010;39:1362–1369.CrossRefGoogle ScholarPubMed
Dion, G.L., Tohen, M., Anthony, W.A., Waternaux, C.S.Symptoms and functioning of patients with bipolar disorder six months after hospitalization. Hosp Community Psychiatry 1988;39:652–657.Google ScholarPubMed
Dragt, S., Nieman, D.H., Veltman, D., Hiske, E., Becker, H.E., van de Fliert, R.et al.Environmental factors and social adjustment as predictors of a first psychosis in subjects at ultrahigh risk. Schizophr Res 2011;125:69–76.CrossRefGoogle Scholar
Edwards, J., McGorry, P.D., Waddell, F.M., Harrigan, S.M.Enduring negative symptoms in first-episode psychosis: comparison of six methods using follow-up data. Schizophr Res 1999;40:147–158.CrossRefGoogle ScholarPubMed
Fenton, W.S., McGlashan, T.H.Antecedents, symptom progression, and long-term outcome of the deficit syndrome in schizophrenia. Am J Psychiatry 1994;151:351–356.Google Scholar
First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B.W.Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Arlington, USA: American Psychiatric Publishing; 1997.Google Scholar
Fusar-Poli, P., Bonoldi, I., Yung, A.R., Borgwardt, S., Kempton, M.J., Valmaggia, L.et al.Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatr 2012;69:220–229.CrossRefGoogle ScholarPubMed
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A.M.D., Schultze-Lutter, F.et al.The psychosis high-risk state: a comprehensive state-of-the-art review. Arch Gen Psychiatry 2012;19:1–14.Google Scholar
Fusar-Poli, P., Bechdolf, A., Taylor, M.J., Bonoldi, I., Carpenter, W.T., Yung, A.R.et al.At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk. Schizophr Bull 201210.1093/schbul/sbs060.Google ScholarPubMed
Galletly, C.A., Clark, C.R., McFarlane, A.C., Weber, D.L.Relationships between changes in symptom ratings, neurophysiological test performance and quality of life in schizophrenic patients treated with clozapine. Psychiat Res 1997;72:161–166.CrossRefGoogle ScholarPubMed
Garmezy, N., Rodnick, E.H.Premorbid adjustment and performance in schizophrenia: implications for interpreting heterogeneity in schizophrenia. J Nerv Ment Dis 1959;129:450–466.CrossRefGoogle Scholar
Gittelman-Klein, R., Klein, D.F.Premorbid asocial adjustment and prognosis in schizophrenia. J Psychiatr Res 1969;7:35–53.CrossRefGoogle Scholar
Glatt, S.J., Stone, W.S., Faraone, S.V., Seidman, L.J., Tsuang, M.T.Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia. Br J Psychiatry 2006;189:337–345.CrossRefGoogle ScholarPubMed
Haas, G.L., Sweeney, J.A.Premorbid and onset features of first-episode schizophrenia. Schizophr Bull 1992;18:373–386.CrossRefGoogle ScholarPubMed
Häfner, H., an der Heiden, W.Epidemiology of schizophrenia. Can J Psychiatry 1997;42:139–151.CrossRefGoogle ScholarPubMed
Häfner, H., Maurer, K., Löffler, W., Riecher-Rössler, A.The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry 1993;162:80–86.CrossRefGoogle ScholarPubMed
Hall, R.C.Global assessment of functioning: a modified scale. Psychosomatics 1995;36:267–275.CrossRefGoogle ScholarPubMed
Henry, A.D., Coster, W.J.Predictors of functional outcome among adolescents and young adults with psychotic disorders. Review. Am J Occup Ther 1996;50:171–181.CrossRefGoogle Scholar
Ho, B.C., Nopoulos, P., Flaum, M., Arndt, S., Andreasen, N.C.Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life. Am J Psychiat 1998;155:1196–1201.CrossRefGoogle ScholarPubMed
Honkonen, T., Stengård, E., Virtanen, M., Salokangas, R.K.Employment predictors for discharged schizophrenia patients. Soc Psychiatry Psychiatr Epidemiol 2007;42:372–380.CrossRefGoogle ScholarPubMed
Johnstone, E.C., Ebmeier, K.P., Miller, P., Owens, D.G., Lawrie, S.M.Predicting schizophrenia: findings from the Edinburgh High-Risk Study. Br J Psychiatry 2005;186:18–25.CrossRefGoogle ScholarPubMed
Keefe, R.S., Mohs, R.C., Losonczy, M.F.et al.Premorbid socio-sexual functioning and long-term outcome in schizophrenia. Am J Psychiatry 1989;146:206–211.Google Scholar
Kelley, M.E., Gilbertson, M., Mouton, A., van Kammen, D.P.Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients. Am J Psychiatry 1992;149:1543–1548.Google ScholarPubMed
Kessler, R.C., Barker, P.R., Colpe, L.J., Epstein, J.F., Gfroerer, J.C., Hiripi, E.et al.Screening for serious mental illness in the general population. Arch Gen Psychiatry 2003;60:184–189.CrossRefGoogle ScholarPubMed
Klosterkötter, J., Ruhrmann, S., Schultze-Lutter, F., Salokangas, R.K.R., Linszen, D., Birchwood, M.et al.The European Prediction of Psychosis Study (EPOS): integrating early recognition and intervention in Europe. World Psychiatry 2005;4:161–167.Google ScholarPubMed
Klosterkötter, J., Schultze-Lutter, F., Bechdolf, A., Ruhrmann, S.Prediction and prevention of schizophrenia: what has been achieved and where to go next?. World Psychiatry 2011;10:165–174.CrossRefGoogle ScholarPubMed
Langfeldt, G.The schizophreniform states. Köbenhavn: Munksgaard; 1939.Google Scholar
Larsen, T.K., McGlashan, T.H., Johannessen, J.O., Vibe-Hansen, L.First-episode schizophrenia: II. premorbid patterns by gender. Schizophr Bull 1996;22:257–269.CrossRefGoogle ScholarPubMed
Lehman, A.F.Vocational rehabilitation in schizophrenia. Schizophr Bull 1995;21:645–656.CrossRefGoogle Scholar
Leung, A., Chue, P.Sex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand 2000;401:3–38.CrossRefGoogle ScholarPubMed
Lindström, L.H.Clinical and biological markers for outcome in schizophrenia: a review of a longitudinal follow-up study in Uppsala schizophrenia research project. Neuropsychopharmacology 1996;14:23–26.CrossRefGoogle ScholarPubMed
Lo, W.H., Lo, T.A ten-year follow-up study of Chinese schizophrenics in Hong Kong. Br J Psychiatry 1977;131:63–66.CrossRefGoogle ScholarPubMed
MacCabe, J.H., Lambe, M.P., Cnattingius, S., Torrang, A., Bjork, C., Sham, P.et al.Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study. Psychol Med 2008;38:1133–1140.CrossRefGoogle ScholarPubMed
MacEwan, T.H., Athawes, R.W.The Nithsdale Schizophrenia Surveys. XV. Social adjustment in schizophrenia: associations with gender, symptoms and childhood antecedents. Acta Psychiatr Scand 1997;95:254–258.CrossRefGoogle ScholarPubMed
Malla, A.K., Norman, R.M., Takhar, J., Rahul, M., Laurel, T., Derek, S.et al.Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?. J Nerv Ment Dis 2004;192:455–463.CrossRefGoogle ScholarPubMed
Marwaha, S., Johnson, S.Schizophrenia and employment. A review. Soc Psychiatry Psychiatric Epidemiol 2004;39:337–349.CrossRefGoogle ScholarPubMed
Mausbach, B.T., Moore, R., Bowie, C., Cardenas, V., Patterson, T.L.A review of instruments for measuring functional recovery in those diagnosed with psychosis. Schizophr Bull 2009;35:307–318.CrossRefGoogle ScholarPubMed
McGlashan, T.H.A selective review of recent North American long-term follow-up studies of schizophrenia. Schizophr Bull 1988;14:515–542.CrossRefGoogle ScholarPubMed
McGlashan, T.H.Early detection and intervention of schizophrenia: rationale and research. Br J Psychiatry Suppl 1998;172:3–6.CrossRefGoogle ScholarPubMed
McGlashan, T.H.Premorbid adjustment, onset types, and prognostic scaling: still informative? Review. Schizophr Bull 2008;34:801–805.CrossRefGoogle Scholar
McGlashan, T.H., Miller, T.J., Woods, S.W.et al.Structured Interview for Prodromal Syndromes Version 3.0. Connecticut: PRIME Research Clinic, Yale School of Medicine; 2001. [Unpublished manuscript New Haven].Google Scholar
McGorry, P.D., Yung, A.R., Phillips, L.J., Yuen, H.P., Francey, S., Cosgrave, E.M.et al.Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatr 2002;59:921–928.CrossRefGoogle Scholar
McGovern, D., Hemmings, P., Cope, R., Lowerson, A.Long-term follow-up of young Afro-Caribbean Britons and white Britons with a first admission diagnosis of schizophrenia. Soc Psychiatry Psychiatr Epidemiol 1994;29:8–19.Google ScholarPubMed
Melau, M., Jeppesen, P., Thorup, A., Bertelsen, M., Petersen, L., Gluud, C.et al.The effect of five years versus two years of specialised assertive intervention for first episode psychosis – OPUS II: study protocol for a randomized controlled trial. Trials 2011;12:72.CrossRefGoogle ScholarPubMed
Miller, T.J., McGlashan, T.H., Rosen, J.L., Somjee, L., Markovich, P.J., Stein, K.et al.Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am J Psychiatr 2002;159:863–865.CrossRefGoogle ScholarPubMed
Miller, T.J., Zipursky, R.B., Perkins, D., Addington, J., Woods, S.W., Hawkins, K.A.et al.The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. I. Study rationale and design. Schizophr Res 2003;61:7–18.CrossRefGoogle Scholar
Morgan, V.A., Castle, D.J., Jablensky, A.V.Do women express and experience psychosis differently from men? Epidemiological evidence from the Australian National Study of Low Prevalence (Psychotic) Disorders. Aust NZ J Psychiatry 2008;42:74–82.CrossRefGoogle ScholarPubMed
Morrison, A.P., French, P., Walford, L., Shôn, W.L., Kilcommons, A., Green, J.et al.Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial. Br J Psychiatry 2004;185:291–297.CrossRefGoogle ScholarPubMed
Mueser, K.T., Becker, D., Torrey, W.C.M., Xie, H., Bond, G.R., Drake, R.G.et al.Work and nonvocational domains of functioning in persons with severe mental illness: a longitudinal analysis. J Nerv Ment Dis 1997;185:419–426.CrossRefGoogle ScholarPubMed
Mueser, K.T., Salyers, M.P., Mueser, P.R.A prospective analysis of work in schizophrenia. Schizophr Bull 2001;27:281–296.CrossRefGoogle Scholar
Nieman, D.H., Velthorst, E., Becker, H.E., de Haan, L., Dingemans, P.M., Linszen, P.H.et al.The Strauss and Carpenter Prognostic Scale in subjects clinically at high risk of psychosis. Acta Psychiatr Scand 2013;127:53–61.CrossRefGoogle ScholarPubMed
Noreik, K., Astrup, C., Dalgard, O.S., Holmboe, R.A prolonged follow-up of acute schizophrenic and schizophreniform psychoses. Acta Psychiatr Scand 1967;43:432–443.CrossRefGoogle ScholarPubMed
Norman, R., Malla, A., Manchanda, R., Townsend, L.Premorbid adjustment in first episode schizophrenia spectrum disorders: a comparison of social and academic domains. Acta Psychiat Scand 2005;112:30–39.CrossRefGoogle Scholar
Nuttall, R.L., Solomon, L.F.Factorial structure and prognostic significance of premorbid adjustment in schizophrenia. J Consult Psychol 1965;29:362–372.CrossRefGoogle Scholar
Olin, S.S., Mednick, S.A., Cannon, T., Jacobsen, B., Parnas, J., Schulsinger, F.et al.School teacher ratings predictive of psychiatric outcome 25 years later. Br J Psychiatry 1998;172:7–13.CrossRefGoogle ScholarPubMed
Owens, D.G., Johnstone, E.C.Precursors and prodromata of schizophrenia: findings from the Edinburgh High Risk Study and their literature context. Psychol Med 2006;36:1501–1514.CrossRefGoogle ScholarPubMed
Parnas, J.From predisposition to psychosis: progression of symptoms in schizophrenia. Acta Psychiatr Scand 1999;99:20–29.CrossRefGoogle Scholar
Phillips, L.Case history data and prognosis in schizophrenia. J Nerv Ment Dis 1953;117:515–525.CrossRefGoogle Scholar
Preston, N.J., Orr, K.G., Date, R., Nolan, L., Castle, D.J.Gender differences in premorbid adjustment of patients with first episode psychosis. Schizophr Res 2002;55:285–290.CrossRefGoogle ScholarPubMed
Rabinowitz, J., Harvey, P.D., Eerdekens, M., Davidson, M.Premorbid functioning and treatment response in recent-onset schizophrenia. Br J Psychiatry 2006;189:31–35.CrossRefGoogle ScholarPubMed
Riecher-Rössler, A., Häfner, H.Gender aspects in schizophrenia: bridging the border between social and biological psychiatry. Acta Psychiatr Scand 2000;102:58–62.CrossRefGoogle Scholar
Riecher-Rossler, A., Pflueger, M.O., Aston, J., Borgwardt, S.J., Brewer, W.J., Gschwandtner, U.et al.Efficacy of using cognitive status in predicting psychosis: A 7-year follow-up. Biol Psychiatry 2009;66:1023–1030.CrossRefGoogle ScholarPubMed
Riecher-Rössler, A., Fätkenheuer, B., Löffler, W., Maurer, K., Häfner, H.Is age of onset in schizophrenia influenced by marital status? Some remarks on the difficulties and pitfalls in the systematic testing a “simple” question. Soc Psychiatry Psychiatr Epidemiol 1992;27:122–128.Google ScholarPubMed
Robertson, D.A., Hargreaves, A., Kelleher, E.B., Morris, D., Gill, M., Corvin, A.et al.Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition. Schizophr Res 2013. http://dx.doi.org/10.1016/j.schres.2013.01.016. [PII: S0920-9964(13)00054-6].CrossRefGoogle ScholarPubMed
Roder-Wanner, U.U., Oliver, J.P., Priebe, S.Does quality of life differ in schizophrenic women and men? An empirical study. Int J Soc Psychiatry 1997;43:129–143.CrossRefGoogle ScholarPubMed
Ruhrmann, S., Schultze-Lutter, F., Salokangas, R.K.R., Heinimaa, M., Linszen, D., Dingemans, P.et al.Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Arch Gen Psychiatry 2010;67:241–251.CrossRefGoogle Scholar
Salokangas, R.K.R.Psychosocial prognosis in schizophrenia. Formation of the prognosis for schizophrenic patients: a multivariate analysis. Annales Universitatis Turkuensis Ser D 1978. [University of Turku, Turku].Google Scholar
Salokangas, R.K.R.Prognostic implications of the sex of schizophrenic patients. Br J Psychiatry 1983;142:145–151.CrossRefGoogle ScholarPubMed
Salokangas, R.K.R., McGlashan, T.H.Early detection and intervention of psychosis. A review. Nord J Psychiatry 2008;62:92–105.CrossRefGoogle ScholarPubMed
Salokangas, R.K.R., Stengård, E.Gender and short-term outcome in schizophrenia. Schizophr Res 1990;3:333–345.CrossRefGoogle Scholar
Salokangas, R.K.R., Räkköläinen, V., Alanen, Y.Maintenance of grip on life and goals of life: a valuable criterion for evaluating outcome in schizophrenia. Acta Psychiatr Scand 1989;80:187–193.CrossRefGoogle Scholar
Salokangas, R.K.R., Honkonen, T., Stengård, E., Koivisto, A.-M.To be or not to be married – that is the question of quality of life in men with schizophrenia. Soc Psychiatry Psychiatr Epidemiol 2001;36:381–390.CrossRefGoogle ScholarPubMed
Salokangas, R.K., Nieman, D.H., Heinimaa, M., Svirskis, T., Luutonen, S., From, T.et al.Psychosocial outcome in patients at clinical high risk of psychosis: a prospective follow-up. Soc Psychiatry Psychiatr Epidemiol 2013;48:303–311.CrossRefGoogle ScholarPubMed
Schlosser, D.A., Jacobson, S., Chen, Q., Sugar, C.A., Niendam, T.A., Li, G.et al.Recovery from an at-risk state: clinical and functional outcomes of putatively prodromal youth who do not develop psychosis. Schizophr Bull 2012;38:1225–1233.CrossRefGoogle Scholar
Schultze-Lutter, F., Klosterkötter, J.Bonn Scale for Assessment of Basic Symptoms – Prediction list, BSABS-P. Cologne: University of Cologne; 2002.Google Scholar
Schultze-Lutter, F., Klosterkötter, J., Michel, C., Winkler, K., Ruhrmann, S.Personality disorders and accentuations in at-risk persons with and without conversion to first-episode psychosis. Early Interv Psychiatry 2012;6:389–398.CrossRefGoogle ScholarPubMed
Seeman, M.V.Current outcome in schizophrenia: women vs. men. Acta Psychiatr Scand 1986;73:609–617.CrossRefGoogle ScholarPubMed
Seeman, M.V., Lang, M.The role of estrogens in schizophrenia gender differences. Review. Schizophr Bull 1990;16:185–194.CrossRefGoogle Scholar
Shepherd, M., Watt, D., Falloon, I., Smeeton, N.The natural history of schizophrenia: a five year follow-up study of outcome and prediction in a representative sample of schizophrenics. Psychol Med Monogr Suppl 1989;15:1–46.CrossRefGoogle Scholar
Shrivastava, A., Shah, N., Johnston, M., Stitt, L., Thakar, M.Predictors of long-term outcome of first-episode schizophrenia: a ten-year follow-up study. Ind J Psychiatry 2010;52:320–326.CrossRefGoogle ScholarPubMed
Shtasel, D.L., Gur, R.E., Gallacher, F., Heimberg, C., Cannon, T., Gur, R.C.Phenomenology and functioning in first-episode schizophrenia. Schizophr Bull 1992;18:449–462.CrossRefGoogle ScholarPubMed
Söderberg, P., Tungström, S., Armelius, B.Å.Reliability of global assessment of functioning ratings made by clinical psychiatric staff. Psychiatric Services 2005;56:434–438.Google ScholarPubMed
Sourander, A., Multimäki, P., Nikolakaros, G., Haavisto, A., Ristkari, T., Helenius, H.et al.Childhood predictors of psychiatric disorders among boys: a prospective community-based follow-up study from age 8 years to early adulthood. J Am Acad Child Adolesc Psychiatry 2005;44:756–767.CrossRefGoogle ScholarPubMed
Stephens, J.H.Long-term prognosis and follow-up in schizophrenia. Schizophr Bull 1978;4:25–47.CrossRefGoogle Scholar
Stephens, J.H., Astrup, C., Mangrum, J.C.Prognosis in schizophrenia. Prognostic scales cross-validated in American and Norwegian patients. Arch Gen Psychiatry 1967;16:693–698.CrossRefGoogle Scholar
Strauss, J.R., Carpenter, W.T.The prediction of outcome in schizophrenia. II. Relationships between predictor and outcome variables. Arch Gen Psychiatry 1974;31:37–42.CrossRefGoogle ScholarPubMed
Tarbox, S.I., Brown, L.H., Haas, G.L.Diagnostic specificity of poor premorbid adjustment: comparison of schizophrenia, schizoaffective disorder, and mood disorder with psychotic features. Schizophr Res 2012;141:91–97.CrossRefGoogle ScholarPubMed
Thorup, A., Petersen, L., Jeppesen, P., Ohlenschlæger, J., Christensen, T., Krarup, G.et al.Gender differences in young adults with first-episode schizophrenia spectrum disorders at baseline in the Danish OPUS study. J Nerv Ment Dis 2007;195:396–405.Google ScholarPubMed
Thorup, A., Albert, N., Bertelsen, M., Jeppesena, P., Le Quackb, P., Krarupb, G.et al.Gender differences in first-episode psychosis at 5-year follow-up - two different courses of disease? Results from the OPUS study at 5-year follow-up. Eur Psychiatry 2013. http://dx.doi.org/10.1016/j.eurpsy.2012.11.005. [PII: S0924-9338(12)00141-1].Google ScholarPubMed
Tsang, M.M., Man, D.W.A virtual reality-based vocational training system (VRVTS) for people with schizophrenia in vocational rehabilitation. Schizophr Res 2013;144:51–62.CrossRefGoogle ScholarPubMed
Tsang, H.W., Leung, A.Y., Chung, R.C., Bell, M., Cheung, W.M.Review on vocational predictors: a systematic review of predictors of vocational outcomes among individuals with schizophrenia: an update since 1998. Aust NZ J Psychiat 2010;44:495–504.Google ScholarPubMed
Twamley, E.W., Vella, L., Burton, C.Z., Becker, D.R., Bell, M.D., Jeste, D.V.The efficacy of supported employment for middle-aged and older people with schizophrenia. Schizophr Res 2012;135:100–104.CrossRefGoogle ScholarPubMed
Vaillant, G.E.The prediction of recovery in schizophrenia. J Nerv Ment Dis 1962;135:534–543.CrossRefGoogle Scholar
van Mastrigt, S., Addington, J.Assessment of premorbid function in first-episode schizophrenia: modifications to the Premorbid Adjustment Scale. J Psychiatry Neurosci 2002;27:92–101.Google ScholarPubMed
Velthorst, E., Nieman, D.H., Becker, H.E., van de Fliert, R., Dingemans, P.M., Peter, M.et al.Baseline differences in clinical symptomatology between ultra-high risk subjects with and without a transition to psychosis. Schizophr Res 2009;109:60–65.CrossRefGoogle ScholarPubMed
Wexler, B.E., Bell, M.D.Cognitive remediation and vocational rehabilitation for schizophrenia. Schizophr Bull 2005;31:931–941.CrossRefGoogle Scholar
White, C., Stirling, J., Hopkins, R., Morris, J., Montaque, L., Tantam, D.et al.Predictors of 10-year outcome of first-episode psychosis. Psychol Med 2009;39:1447–1456.CrossRefGoogle ScholarPubMed
Williams, P.V., McGlashan, T.H.Schizoaffective psychosis. I. Comparative long-term outcome. Arch Gen Psychiatry 1987;44:130–137.CrossRefGoogle ScholarPubMed
Yung, A.R., Phillips, L.J., Yuen, H.P., Francey, S.M., McFarlane, C.A., Hallgren, M.Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophr Res 2003;60:21–32.CrossRefGoogle ScholarPubMed
Zigler, E., Phillips, L.Social competence and outcome in psychiatric disorders. J Abnorm Soc Psychol 1961;63:264–271.CrossRefGoogle Scholar
Zigler, E., Phillips, L.Social competence and the process-reactive distinction in psychopathology. J Abnorm Soc Psychol 1962;65:215–222.CrossRefGoogle ScholarPubMed
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