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Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings

Published online by Cambridge University Press:  16 April 2020

I. Michopoulos ,
I.M. Zervas ,
V.M. Papakosta ,
E. Tsaltas ,
C. Papageorgiou ,
T. Manessi ,
Y.G. Papakostas ,
L. Lykouras  and
C.R. Soldatos
I. Michopoulos*
Affiliation:
2nd Department of Psychiatry, Athens University Medical School, “Attikon” General Hospital, 1 Rimini Street, 124 62Athens, Greece
I.M. Zervas
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
V.M. Papakosta
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
E. Tsaltas
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
C. Papageorgiou
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
T. Manessi
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
Y.G. Papakostas
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
L. Lykouras
Affiliation:
2nd Department of Psychiatry, Athens University Medical School, “Attikon” General Hospital, 1 Rimini Street, 124 62Athens, Greece
C.R. Soldatos
Affiliation:
Department of Psychiatry, Athens University Medical School, “Eginiton” Hospital, Athens, Greece
*
*Corresponding author. Tel.: +30 210 583 2426; fax: +30 210 532 6453. E-mail address: [email protected] (I. Michopoulos).
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Abstract

Twenty-two patients with major depressive disorder, 11 of them with melancholic features, and 11 controls were investigated with CANTAB subtests focusing in visual memory/learning and executive functions. Melancholic patients performed worse than the other groups in all tasks and manifested a significant impairment in set shifting. The results are discussed in association with prefrontal dysfunction.

Keywords

Cambridge Neuropsychological Test Automated Battery (CANTAB)DepressionMelancholic featuresSet shifting
Type
Rapid communication
Information
European Psychiatry , Volume 21 , Issue 6 , September 2006 , pp. 361 - 363
Copyright
Copyright © Elsevier SAS 2006

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