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Seasonal distribution of births in patients with Alzheimer’s disease and elderly depressive patients

Published online by Cambridge University Press:  16 April 2020

U. Ptok ,
A. Papassotiropoulos ,
W. Maier  and
R. Heun
U. Ptok*
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-St. 25 53105, Bonn, Germany
A. Papassotiropoulos
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-St. 25 53105, Bonn, Germany
W. Maier
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-St. 25 53105, Bonn, Germany
R. Heun
Affiliation:
Department of Psychiatry, University of Bonn, Sigmund-Freud-St. 25 53105, Bonn, Germany
*
*Correspondence and reprints. E-mail address: [email protected] (U. Ptok).
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Summary

Winter births have been associated with a higher risk of Alzheimer’s disease (AD) and other psychiatric disorders. In the present investigation, this putative association was examined in a sample of gerontopsychiatric patients. An analysis of the quarterly birth rates of 83 patients with AD, 78 elderly depressive patients with an early onset and 74 patients with a late onset of the depressive disorder, 48 patients with both AD and depression (co-morbid patients) and 107 healthy control subjects, revealed no particular seasonal distribution for any of the diagnostic groups. In AD and co-morbid patients, controlling for the ApoE genotype did not change this finding. Logistic regression analysis revealed the expected findings that increasing age and the presence of the ApoE4 allele were associated with a higher risk of dementia. Younger age and female gender were identified as risk factors for a depressive disorder. A winter birth (birth in the first three months of the year) was not associated with any of the diagnostic subgroups.

We concluded that in our sample a seasonal distribution of births was not found to increase the risk for AD or geriatric depression.

Keywords

Alzheimer's diseaseApoE genotypedepression in the elderlyseason of birth
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 3 , April 2001 , pp. 157 - 161
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2001

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References

Andreasen, NC, Endicott, J, Spitzer, RL, Winokur, G.The family history method using diagnostic criteria. Arch Gen Psychiatry 1977; 34: 1229–1235.CrossRefGoogle ScholarPubMed
Boyd, JH, Pulver, AE, Stewart, W.Season of birth: schizophrenia and bipolar disorder. Schizophr Bull 1986; 12: 173–186.CrossRefGoogle ScholarPubMed
Bradbury, TN, Miller, GA.Season of birth in schizophrenia: a review of evidence, methodology and etiology. Psychol Bull 1985; 98: 569–594.CrossRefGoogle ScholarPubMed
Castrogiovanni, P, Iapichino, S, Pacchierotti, C, Pieraccini, F.Season of birth in psychiatry. A review. Neuropsychobiology 1998; 37: 175–181.CrossRefGoogle ScholarPubMed
Dysken, MW, Kuskowski, M, Skare, SS, Roessmann, U, Noronha, A, Frey, WH 2d. Seasonal distribution of births in Alzheimer’s disease. Int Psychogeriatr 1991; 3: 53–58.CrossRefGoogle ScholarPubMed
Fratiglioni, L, Ahlbom, A, Viitanen, M, Winblad, B.Risk factors for late-onset Alzheimer’s disease: a population based, case control study. Ann Neurol 1993; 33: 258–266.CrossRefGoogle ScholarPubMed
Fratiglioni, L, Viitanen, M, von Strauss, E, Tontodonati, V, Herlitz, A, Winblad, B.Very old women at highest risk of dementia and Alzheimer’s disease: incidence data from the Kungsholmen project, Stockholm. Neurology 1997; 48: 132–138.CrossRefGoogle ScholarPubMed
Gao, S, Hendrie, HC, Hall, KS, Hui, S.The relationships between age, sex, and the incidence of dementia and Alzheimer’s disease. Arch Gen Psychiatry 1998; 55: 809–815.CrossRefGoogle Scholar
Hare, EH.Mental disorder and season of birth: a rational sample compared with the general population. Br J Psychiatry 1974; 124: 81–86.CrossRefGoogle Scholar
Hare, EH.Manic-depressive psychosis and season of birth. Acta Psychiatr Scand 1975; 52: 69–79.CrossRefGoogle ScholarPubMed
Henderson, AS, Korten, AE, Jorm, AF, McCusker, E, Creasy, H, Broe, GA.Season of birth for Alzheimer’s disease in the southern hemisphere. Psychol M 1991; 21: 371–374.CrossRefGoogle ScholarPubMed
Heun, R, Hardt, J, Müller, H, Maier, W.Selection bias during recruitment of elderly subjects from the general population for psychiatric interviews. Eur Arch Psychiatry Clin Neurosci 1997; 247: 87–92.CrossRefGoogle ScholarPubMed
Jorm, AF, Jolley, D.The incidence of dementia. A meta-analysis. Neurology 19XX; 51: 728–733.CrossRefGoogle Scholar
Modestin, J, Ammann, R, Würmle, O.Season of birth: comparison of patients with schizophrenia, affective disorders and alcoholism. Acta Psychiatr Scand 1995; 91: 140–143.CrossRefGoogle ScholarPubMed
Payami, H, Montee, K, Grimslid, H, Shattuc, S, Kaye, J.Increased risk of familial late-onset Alzheimer’s disease in women. Neurology 1996; 46: 126–129.CrossRefGoogle ScholarPubMed
Philpot, M, Rottenstein, M, Burns, A, Der, G.Season of birth in Alzheimer’s disease. Br J Psychiatry 1989; 155: 662–666.CrossRefGoogle ScholarPubMed
Prince, M, Cullen, M, Mann, A.Risk factors for Alzheimer’s disease and dementia: A case-control study based on the MRC elderly hypertension trial. Neurology 1994; 44: 97–104.Google ScholarPubMed
Prince, MJ, Harwood, RH, Thomas, A, Mann, AH.A prospective population-based cohort study of the effects of disablement and social milieu on the onset and maintenance of late-life depression. Psychol M 1998; 25: 337–350.CrossRefGoogle Scholar
Rhimer, Z.Season of birth and season of hospital admission in bipolar depressed female patients. Psychiatry Res 1980; 3: 247–251.CrossRefGoogle Scholar
Robins, LN, Helzer, JC, Weissman, MM, Orvaschel, H, Gruenberg, E, Burke, JDet al. Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry 1984; 41: 949–958.CrossRefGoogle ScholarPubMed
Saunders, AM, Strittmatter, WJ, Schmechel, D, George-Hyslop, PH, Pericak-Vance, MA, Joo, SHet al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 1993; 43: 1467–1472.CrossRefGoogle ScholarPubMed
St Clair, D, Rennie, M, Slorach, E, Norrman, J, Yates, C, Carothers, A.Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer’s disease in both homozygote and heterozygote carriers. J Med Genet 1995; 32: 642–644.CrossRefGoogle ScholarPubMed
Torrey, EF, Miller, J, Rawlings, R, Yolken, RH.Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 1997; 28: 1–38.CrossRefGoogle ScholarPubMed
Vezina, H, Houde, L, Charbonneau, H, Beaudry, M, Cholette, A, Daoud, Net al. Season of birth and Alzheimer’s disease: a population-based study in Saguenay-Lac-St-Jean/Quebec (IMAGE Project). Psychol M 1996; 26: 143–149.CrossRefGoogle Scholar
Vitiello, B, Hill, JL, Molchan, SE, Martinez, RA, Martinson, HJ, Sunderland, T.Lack of seasonal variation in the births of patients with dementia of the Alzheimer type. Psychiatry Res 1991; 39: 21–24.CrossRefGoogle ScholarPubMed
World Health Organisation. Composite International Diagnostic Interview. Geneva: World Health Organisation, Division of Mental Health; 1990.Google Scholar
Zaudig, M, Mittelhammer, J, Hiller, W, Pauls, A, Thora, C, Morinigo, Aet al. SIDAM – a structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-111-R. Psychol M 1991; 21: 225–236.CrossRefGoogle Scholar
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