Research in interventions in schizophrenia spectrum disorders in Denmark has taken place in a loose network, which during the years have grown in size and had become increasingly organised. The randomised clinical trial: OPUS: Early Intervention in First Episode Psychosis was the first large two-site trial which took place in Copenhagen and Aarhus. Thereafter came the randomised clinical trial: NEUROCOM, Neurocognition and competence in schizophrenia which is also a two-site project. Evaluation of the effect of assertive community treatment in a quasi-experimental design in three cities is another example.

Parallel to this activity the Danish Schizophrenia Guidelines was developed and endorsed in Danish National Board of Health and the Danish National Indicator Project evaluated the quality of schizophrenia treatment in Denmark.

All first episode psychosis programmes meet once a year to discuss results of projects and future plans. A Danish Psychiatric Research Programme was formed to host the training.