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S22.03 - Influences of snap-25 polymorphisms on cognition and MRS spectra in psychoses and OCD

Published online by Cambridge University Press:  16 April 2020

P. Falkai ,
H. Scherk ,
M. Backens ,
T. Schneider-Axmann ,
T. Wobrock ,
W. Reith ,
H.J. Möller ,
B. Bondy  and
O. Gruber
P. Falkai
Affiliation:
Department of Psychiatry and Psychotherapy, Georg-August-University, Goettingen, Germany
H. Scherk
Affiliation:
Department of Psychiatry and Psychotherapy, Georg-August-University, Goettingen, Germany
M. Backens
Affiliation:
Department of Neuroradiology, Saarland University Hospital, Homburg, Germany
T. Schneider-Axmann
Affiliation:
Department of Psychiatry and Psychotherapy, Georg-August-University, Goettingen, Germany
T. Wobrock
Affiliation:
Department of Psychiatry and Psychotherapy, Georg-August-University, Goettingen, Germany
W. Reith
Affiliation:
Department of Neuroradiology, Saarland University Hospital, Homburg, Germany
H.J. Möller
Affiliation:
Department of Psychiatry and Psychotherapy, LM University of Munich, Munich, Germany
B. Bondy
Affiliation:
Department of Psychiatry and Psychotherapy, LM University of Munich, Munich, Germany
O. Gruber
Affiliation:
Department of Psychiatry and Psychotherapy, Georg-August-University, Goettingen, Germany

Abstract

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Background:

The SNAP-25 gene is an integral part of the vesicle docking and fusion machinery that controls the neurotransmitter release from the vesicles of the presynaptic neuron into the synaptic cleft. Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder.

Methods:

38 patients with schizophrenia, bipolar disorder or obsessive-compulsive disorder and 15 healthy controls participated in the study. Proton magnetic resonance spectroscopy in left hippocampus was performed in each individual. Three single nucleotide polymorphisms (SNP) of the SNAP-25 gene were genotyped.

Results:

Individuals with the homozygous CC genotype of the DdeI SNP presented a significantly higher ratio of NAA/Cho in the left hippocampus compared to the group of individuals with the homozygous TT genotype.

Conclusions:

The present findings are consistent with the view that the SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus, and that an altered NAA/Cho ratio may be an indicator for this genetic modulation of neuronal function in the hippocampus.

Type
Symposium: Genomic imaging – affect and psychoses
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S19
Copyright
Copyright © European Psychiatric Association 2008
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