Medical curricula in Central and Eastern Europe share the tradition and transformation of the university training under the strong German influence, modified by decades of communistic educational system. This tradition is characterized mainly by the classical educational formats (plenary lectures and practices), by the split of a discipline into “general” (psychopathology) and “special” (diseases) parts, and by predominating medical approach based on Kraepelinian nosological system. In recent decades, however, more problem oriented, integrated and interactive style of medical training penetrated also into this part of Europe. It was reflected by the introduction of new medical curricula with diversified teachings psychiatry in different modules including applied neuroscience, medical ethics, patient oriented approach and modern educational formats including electives in psychotherapy, biological psychiatry, psychopathology, assessment techniques, and methodology. Psychiatry becomes to be a part of modules such as pain, dyspnoea, basic medical problems and broader medical context. Neurobehavioral sciences are now more integrated and clinical rotation is more practically oriented (problem oriented). The example of a new curriculum introduced at the Third Medical School of Charles University in Prague will be presented.