Harm reduction program in Bosnia and Herzegovina exist only in a form of methadone treatment. This program started in early eighties of the last century.

During the war, this program was unfortunately interupted, and it is revitalized at the beginning of 2002, as an answer to increasing number of addicts during the post-war period.

Recently, we atarted to make first steps in implementation of other harm reduction programs such as needle exchange, prevention of sexually transmitted diseases, and similar.

In this paper we will present three year experience in application of methadone in treatment in our Methadone Maintenance Treatment Center for 190 clients.

We will also try to present our experiences and effectiveness of this type of treatment trough examples from practice, as well as by epidemiological and statistical data.