Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-19T10:48:54.646Z Has data issue: false hasContentIssue false
  • English
  • Français

The role of beta-carbolines (harman/norharman) in heroin addicts

Published online by Cambridge University Press:  16 April 2020

R Stohler ,
H Rommelspacher  and
D Ladewig
R Stohler
Affiliation:
Department of Psychiatry, University of Basel, CH-4025Basel, Switzerland
H Rommelspacher
Affiliation:
Institute of Neuropsychopharmacology, Freie University of Berlin, D-14050Berlin, Germany
D Ladewig
Affiliation:
Department of Psychiatry, University of Basel, CH-4025Basel, Switzerland
Get access

Summary

Endogenous substances resulting from interactions between alcohol and possibly opioid metabolites and neurotransmitters (dopamine, indolamines) could be mediators of the pathochemical process towards dependence. Beta-carbolines (harman/norharman) are increased in alcoholics and — according to the presented results — in heroin addicts. Psychopathological disorders such as anxiety or depression do not seem to influence the level of beta-carbolines.

Keywords

beta-carbolinesheroin dependenceharmannorhannan
Type
Rapid communication
Information
European Psychiatry , Volume 10 , Issue 1 , 1995 , pp. 56 - 58
Copyright
Copyright © Elsevier, Paris 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Schuckit, MAPopulation genetically at high risk of developing alcohol abuse or dependence. Curr Opin Psychiatry. 1990;3: 375–910.1097/00001504-199006000-00010CrossRefGoogle Scholar
Rommelspacher, HBüchau, CWeiss, JHarman induces preference for ethanol in rats: Is the effect specific for ethanol?. Pharmacol Biochem Behav. 1987;26: 749–55CrossRefGoogle ScholarPubMed
Rommelspacher, HSchmidt, LGMay, TPlasma norharman (beta-carboline) levels are elevated in chronic alcoholics. Alcoholism: Clin Exp Res. 1991;15: 553–9CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.