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Relationship between different PANSS cognitive factors and cognition assessed with MCCB in patients with first psychotic episode of schizophrenia

Published online by Cambridge University Press:  27 August 2024

R. Rodriguez-Jimenez*
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12) 2CIBERSAM, Madrid, Spain
Á. Sánchez-Cabezudo
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
M. Scala
Affiliation:
3Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy
L. García-Fernández
Affiliation:
2CIBERSAM, Madrid, Spain 4Psychiatry, Universidad Miguel Hernández, Alicante
L. Sánchez-Pastor
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
D. Rentero
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
I. Martínez-Gras
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
M. Caballero
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
J. M. Espejo-Saavedra
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
A. Nuñez-Doyle
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
O. Jiménez-Rodríguez
Affiliation:
1Psychiatry, Instituto de Investigación Hospital 12 de Octubre (imas12)
A. I. Aparicio-León
Affiliation:
2CIBERSAM, Madrid, Spain 5Psychiatry, Hospital Virgen de la Luz, Cuenca, Spain
J. L. Santos
Affiliation:
2CIBERSAM, Madrid, Spain 5Psychiatry, Hospital Virgen de la Luz, Cuenca, Spain
*
*Corresponding author.

Abstract

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Introduction

The Positive and Negative Syndrome Scale (PANSS) has been used as a universal instrument for clinical assessment of psychopathology in schizophrenia. Different studies have analyzed the factorial structure of this scale and have suggested a five-factor model: positive, negative, excited, depressive, and cognitive/disorganized factors. Two of the most used models are the Marder´s solution and the Wallwork´s one.

Objectives

The aim of this work was to study the correlations of the two cognitive factors (Marder and Wallwork) with a cognitive assessment performed with a standard cognitive battery, in a sample of patients with first psychotic episode of schizophrenia.

Methods

Seventy four patients with first psychotic episode of schizophrenia (26.9, SD:7.8 years old; 70.3% male) were included. The cognitive assessment was performed with the MATRICS Consensus Cognitive Battery (MCCB). The MCCB present seven cognitive domains: Speed of processing, Working memory, Attention/Vigilance, Verbal Learning, Visual Learning, Reasoning and Problem Solving, and Social cognition). Pearson correlations were performed between MCCB scores and Marder´s PANSS cognitive factor (P2, N5, G5, G10, G11, G13, G15) and Wallwork´s one (P2, N5, G11).

Results

Correlation between MCCB scores and cognitive factors of Marder and Wallwork can be seen in the table.

Marder´s cognitive factorWallwork´s cognitive factor
Speed of processingr = -0.461; p<0.001r = -0.455; p<0.001
Attention/Vigilancer = -0.414; p<0.001r = -0.415; p<0.001
Working memoryr = -0.449; p<0.001r = -0.468; p<0.001
Verbal Learningr = -0.511; p<0.001r = -0.405; p<0.001
Visual Learningr = -0.252; p=0.024r = -0.254; p=0.029
Reasoning and Problem Solvingr = -0.244; p=0.036r = -0.272; p=0.019
Social cognitionr = -0.268; p=0.024r = -0.202; p=0.091

Conclusions

Both PANSS cognition factors show a moderate correlations with Speed of processing, Working memory, Attention/Vigilance and Verbal Learning assessed by MCCB. More discrete correlations were found with Visual Learning, Reasoning and Problem Solving, and with Social cognition (in fact, non-significant correlation with Wallwork´s cognitive factor was found).

Acknowledgements. This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI19/00766 and co-funded by the European Union.

Disclosure of Interest

None Declared

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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