No CrossRef data available.
Article contents
Relation Between Long Term Antipsychotic Treatment and Osteoporosis
Published online by Cambridge University Press: 15 April 2020
Abstract
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background and Aim of Work
Osteoporosis and frequent fractures are reported in schizophrenic patients, Hyperprolactinemia can be contributing to bone demineralization. Since antipsychotics are themselves the commonest iatrogenic etiology to hyperprolactinemia, long term antipsychotic use may be contributing to osteopenia
Subjects and Methods
30 schizophrenic patients with chronic course receiving antipsychotic for 2-10 years compared to 20 drug naïf schizophrenic patients. Patients on cortisol therapy, debilitating chronic illness or suffering from rheumatic disorders were excluded. Bone density evaluated by Dual energy X ray absorbtiometry and serum level; of prolactine measured
Results
Among schizophrenic patients on medication, 40% were on respiridone, 10% on clozapine, 33.3% on haloperidol and 16.7% on olanzapine.significant difference showed up between schizophrenic patient on medication and drug naïf as regards bone miniral density T score (X2 = 3.25; p< 0.05)
Conclusion
Osteopenia is common among schizophrenic patients receiving prolactine raising antipsychotics, raising the urge to screen for bone density among those with long term use of psychotropes
- Type
- Article: 1729
- Information
- European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
- Copyright
- Copyright © European Psychiatric Association 2015
You have
Access
Comments
No Comments have been published for this article.