Patients suffering from chronic diseases develop depressive disorders with increased frequency. In uremic patients, depression is the most widely acknowledged abnormality, affecting both quality of life and treatment compliance. Aim of this study was to investigate incidence of depression and to assess relation to clinical, laboratory parameters and sleep disorders in hemodialysis patients. Psychiatric profile of 45 hemodialysis patients (32 male, 13 female, mean age 59±16,2 years), was evaluated using Hamilton Depression Scale (HAMD). According to scores of the latter, patients were divided into two groups. Group A comprised 29 patients with HAMD score 0-7 (absence of depression), whereas group B included 16 patients scoring higher than 7 (clinically assessed disorder). Subjects were compared in terms of socioeconomic, clinical, laboratory parameters and presence of sleep disorders (assessed by Athens Insomnia Scale, AIS). Non significant difference was observed with respect to age, sex, family status, education, self-esteem, coffee and alcohol consumption, psychiatric history, time in hemodialysis and laboratory (serum urea, creatinine, electrolytes, iron, albumin and lipids) parameters. Group B demonstrated significantly lower hemoglobin levels (11,13±1,69 and 12,23±1,31g/dl respectively, p<0,01) and higher CRP levels (1,82±1,73 and 0,83±0,6mg/dl respectively, p<0,005) compared to group A. Additionally, strong correlation was observed when HAMD scores were related to hemoglobin (r=-0,30, p<0,05), CRP (r=0,38, p<0,001) and AIS scores (r=0,54, p<0,0001). In conclusion, clinically overt depression is common in hemodialysis patients and seems to be related to high CRP and low haemoglobin levels. Moreover, strong correlation to sleep disorders, which are common to such patients, seems to apply.