Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-27T01:36:35.599Z Has data issue: false hasContentIssue false
  • English
  • Français

The reduction of alcohol consumption with novel pharmacological intervention

Published online by Cambridge University Press:  16 April 2020

W Sperling  and
O.M. Lesch
W Sperling
Affiliation:
Department of Psychiatry, Friedrich Alexander University of Erlangen, Schwabachanlage 6-10, 91054Erlangen, Germany
O.M. Lesch
Affiliation:
Department of Psychiatry, Universily of Vienna, Vienna, Austria
Get access

Summary

The development of pharmacological agents in treating alcoholism represents one of many different ways to suppress alcohol intake. Regarding the hypothetical involvement of different neurochemical systems in “alcohol craving”, specific substances have been examined in animals models (especially rats) and increasingly in man. Promising results in reducing “alcohol craving” were described in the use of different kinds of chemical substances. “Craving” therefore can hardly be explained on the basis of a deficit in only one neurochemical (neurotransmitter) system. This conclusion is supported by the data. The efficiacy of many anti-craving substances described in smaller studies must first be confirmed in clinical studies on a wider scale.

Keywords

cravingalcoholismserotoninopioidslithiumacamprosat
Type
Review
Information
European Psychiatry , Volume 11 , Issue 5 , 1996 , pp. 217 - 226
Copyright
Copyright © Elsevier, Paris 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ades, JBarrias, JABesson, JBorg, SLesch, OMGuidelines on evaluation of treatment of alcohol dependence J Alcohol Related Addict 1994 xxx(Suppl)Google Scholar
Amit, ZSmith, BR Neurotransmitter systems in ethanol intake Satellite Symposium to the 5th ISBRA conference —Novel pharmacological interventions for alcoholism — Addiction Research Foundation Toronto, Canada 1990Google Scholar
Bilsky, EJDelconte, J Mianserin, a serotonergic antagonist, and intake of an alcoholism beverage Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism —Addiction Research Foundation Toronto, Canada 1990Google Scholar
Borg, VBromocriptine in the prevention of alcohol abuse Acta Psychiatr Scand 1983 682 100–110CrossRefGoogle ScholarPubMed
Cloninger, CRSigvardsson, SGilligan, SBGenetic heterogeneity and the classification of alcohol Adv Alcohol Subst Abuse 1988 7 3–16CrossRefGoogle Scholar
Compagnon, PSerotonin in animal models of alcoholism Alcohol and Alcoholism 1993 2 215–219Google ScholarPubMed
Diagnostische Kriterien and Differentialdiagnosen des Diag nostischen und statistischen Manuals psychischer Störungen DSM-III-R Weinheim, Basel Beltz 1989Google Scholar
De Vry, J5-HT-1A receptors in anxietyBrilley, MNew Concepts in Anxiety LondonMac Millon 1991 94–129CrossRefGoogle Scholar
Dillon, KAAutographic analysis of serotonin 5-HT-1A receptor binding in the human brain postmortem: Effects of age and alcohol Brain Res 1991 554 56–64CrossRefGoogle Scholar
Dorus, WOstrow, DGAnton, RCushman, PCollins, JFSchaefer, MLithium treatment of depressed and nondepressed alcoholics (comments) JAMA 1989 262 1680–1681CrossRefGoogle Scholar
Engel, JAFahlke, CHard, ESvensson, L Serotonergic involvement in ethanol intake Satellite Symposium to the 5th ISBRA conference — Novel pharmacological interventions for alcoholism — Addiction Research Foundation Toronto, Canada1990Google Scholar
Fawcett, JClark, DCEvaluation of lithium therapy for alcohol ism J Clin Psychiatry 1984 45 494–499Google Scholar
Fawcett, MDClark, DCA double-blind, placebo-controlled trial of lithium carbonate therapy for alcoholism Arch Gen Psychiatry 1987 44 248–256CrossRefGoogle ScholarPubMed
Fröhlich, JCZweifel, MKurtz, D Opioid antagonists selectively suppress ethanol intake Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation, Toronto, Canada, 1990Google Scholar
Gallimberti, LFerri, MFerrara, SDFadda, FGessa, GIGamma-hydroxybutyric acid in the treatment of alcohol dependence: A double-blind study Alcohol Clin Exper Res 1992 164 673–676CrossRefGoogle ScholarPubMed
Gorrelick, DAParedes, AEffects of fluoxetine and alcohol consumption in male alcoholics Alcoholism Clin Exper Res 1992 16 261–265CrossRefGoogle Scholar
Gottlieb, LDHorwitz, RIKraus, MLRandomized controlled trial in alcohol relapse prevention, role of atenolol, alcohool craving and treatment adrherence J Subst Abuse Treat 1994 11 253–258CrossRefGoogle Scholar
Grupp, LA Angiotensin converting enzyme inhibitors reduce alcohol consumption in rats Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation,Toronto, Canada 1990Google Scholar
Higgins, GASellers, EM Strategies for the identification of novel serotonergic treatments to selectively reduce ethanol consumption Satellite Symposium to the 5th ISBRA Con ference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation, Toronto, Canada 1990Google Scholar
Ho, ADTsai, CSEffects of lithium on alcohol preference and withdrawal Ann NY Acad Sci 1976 273 371–377CrossRefGoogle ScholarPubMed
Hubbel, CLChrisbacher, GABilsky, EJReid, LD Angiotensin converting enzyme inhibitors and intake of an alcoholic beverage Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation, Toronto, Canada 1990Google Scholar
Judd, LLHuey, LYLithium antagonizes ethanol intoxication in alcoholics Am J Psychiatry 1984 141 1517–1521Google ScholarPubMed
Kranzler, H Fluvoxamine is poorly tolerated by alcoholics Plenary lecture and panel discussion in: Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism Addiction Research FoundationToronto, Canada 1990Google Scholar
Kranzler, HRBurleson, JADe Boca, FKBuspirone treatment of anxious alcoholics. A placebo-controlled trial Arch Gen Psychiatry 1994 51 720–731CrossRefGoogle ScholarPubMed
Kornet, MBehavioural and neuropharmacological aspects of experimental alcohol addiction in rhesus monkeys Rijswijk TNO 1991Google Scholar
Lejoyeux, MAdes, JEvaluation of lithium treatment in alcoholism Alcohol Alcoholism 1993 28 273–279Google ScholarPubMed
Lesch, OMWalter, HBonte, WGrünberger, JMusalek, MSprung, REtiology of subgroups in chronic alcoholism and different mechanisms in transmitter systemsNorman Palmer, TAlcoholism: a Molecular Perspective Nato Asi Series A: Life sciences Vol 206 New YorkPlenum Press 1993 145–160Google Scholar
Lesch, OMPoldrugo, FThe diagnosis of alcoholism: New perspectives in classification Alcologia 1994 6 11–15Google Scholar
Linnoila, MGeorge, DTWozniak, K Serotonin and alcohol Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism Addiction Research Foundation,Toronto, Canada,1990Google Scholar
Littrell, JUnderstanding and Treating Alcoholism, Vol 2: Biological, Psychological and Social Aspects of Alcohol Consumption and Abuse, New Jersey 1991Google Scholar
Malcom, RA placebo-controlled trial of buspirone in anxious inpatient alcoholics Alcohol Clin Exp Res 1992 16 1007–1013CrossRefGoogle Scholar
Malley, SOJaffe, AChang, GWitte, G Naltrexone treatment of alcohol dependence Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
McBride, WJSerotonin in animal models of alcoholism Alcohol Alcoholism 1990 2 215–219Google Scholar
Merry, JReynolds, CMProphylactic treatment of alcoholism by lithium carbonate Lancet 1976 2 481–482CrossRefGoogle Scholar
Meyer, R Preclinical and clinical methods for testing drugs to decrease alcohol consumption Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Modell, JGMoutz, JMGlaser, FBLee, JYEffect of haloperidol on measures of craving and impaired control in alcoholic subjects Alcohol Clinical Exp Res 1993 172 234–240CrossRefGoogle ScholarPubMed
Naranjo, CAKadlec, KEEllers, EM Evaluation of the effects of serotonin uptake inhibitors in alcoholics: a review Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto,Canada 1990Google Scholar
Naranjo, CASellers, EMKadlec, KSanhueza, PGrupp, L Enalapril does not decrease alcohol intake in normotensive alcoholics Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Naranjo, CABrenner, KEEffects of citalopram and a brief psychosocial intervention on alcohol intake, dependence and problems Addiction 1995 90 87–94CrossRefGoogle Scholar
Nichols, MLBilsky, EDHubbel, CL Peripheral administration of TIQ's and intake of an alcohol beverage Satellite Symposium to the 5th ISBRA Conference — Novel pharmaco- logical interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Nichols, MLHubbel, CLReid, LD Stereoselectivity of opioids effects on intake of an alcoholic beverage Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Olbrich, RWatzl, HVolter, MSiedow, HLithium in der Behandlung chronischer Alkoholkranker mit zerebralen Schädigungen —eine kontrollierte Studie Nervenartz 1991 62 182–186Google Scholar
Opitz, KThe effect of clonidine and related substances on voluntary ethanol consumption in rats Drug Alcohol Depend 1990 25 43–48CrossRefGoogle ScholarPubMed
Pelc, ILebon, OVerbank, PLehert, PHOpsomer, L Calcium acetylhomotaurinate for maintaining abstinence in weaned alcoholic patients Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Reid, LRWong, D5-Hydroxytryptamine-1A receptor in brain areas of alcohol preferring and non-preferring rats Fased J 1991 5 865Google Scholar
Rommelspacher, HSchmidt, LGMay, TPlasma norharman, carboline levels elevated in chronic alcoholics Clin Exp Res 1991 15 553CrossRefGoogle ScholarPubMed
Sano, HCircadian variations in plasma 5-HTAA level during and after withdrawal Acta Psychiat Scand 1993 87 291–296CrossRefGoogle Scholar
Sinclair, JD Preclinical and clinical methods for testing drugs to decrease alcohol consumption Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interven- tions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Schreiber, RDe Vry, JIpsapirone and 8-OH-DPAT reduce ethanol preference in rats: involvement of presynaptic 5-HT-1A receptors Psychopharmacology 1993 112 100–110CrossRefGoogle Scholar
Swift, RMWhelihan, WKutznesov, ONaltrexone induced alterations in human ethanol intoxication Am J Psychiatry 1994 151 1463–1467Google ScholarPubMed
Tollefson, GDSerotonin and alcoholism: Interrelationships Psychopathology 1989 22 37–48CrossRefGoogle ScholarPubMed
Volpicelli, JRAltermann, AIHayashida, MO'Brien, CPNaltrexone in the treatment of alcohol dependence Arch Gen Psychiatry 1992 4911 876–880CrossRefGoogle ScholarPubMed
Volpicelli, JRWatson, NTKing, ACEffect of naltrexone on alcohol “high” in alcoholics Am J Psychiatry 1995 152 613–615Google Scholar
Wong, DTSerotonergic and adrenergic receptors in alcohol preferring and non-preferring rats J Neural Transm 1988 71 207–218CrossRefGoogle ScholarPubMed
Zeise, MLKasparow, MCapogna, MZieglgänsberger, W Calciumdiacetylhomotaurinate decreases the action of excitatory amino acids in the rat neocortex in vitro Satellite Symposium to the 5th ISBRA Conference — Novel pharmacological interventions for alcoholism. Addiction Research Foundation Toronto, Canada 1990Google Scholar
Submit a response

Comments

No Comments have been published for this article.