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PW01-93 - The Effects On The Level Of Intestinal Endotoxemia In Alzheimer Disease Rats
Published online by Cambridge University Press: 17 April 2020
Abstract
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Objective
The objective of the present study was to explore the level of intestinal endotoxemia (IETM) in the model of Alzheimer disease's rats which were established by D-galactose and aluminum trichloride (AlCl3).
Methods
Adult Wistar rats were subjected to 90 days of intraperitoneal injection with D-galactose and AlCl3 to establish the Alzheimer disease's model. After the administration, the study and memory ability of the Alzheimer disease's rats were observed by Morris water maze; The level of Lipopolysaccharide (LPS) in the sera of Alzheimer disease's rats was determined by tachypleus amebocyte lysate method; The level of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) in the sera of Alzheimer disease's rats were determined by radioimmunity method;
Results
Compared with the normal control, the level of LPS, TNF-α and IL-1 in the sera of Alzheimer disease's rats were markedly increased (P< 0.01).
Conclusions
The model of Alzheimer disease's rats which were established by D-galactose and AlCl3 is accompanied IETM.
Keywords
- Type
- Dementia / Gerontopsychiatry
- Information
- Copyright
- Copyright © European Psychiatric Association 2009
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