The objective of the present work was the investigation of the general health level and factors that influence the job satisfaction in a sample of health care workers that they serve in primary, secondary and tertiary health care in Central Greece.

500 professionals of health were administered:

1. a) a closed type questionnaire of job satisfaction evaluation, based on Likert scale, and

2. b) the questionnaire of general health GHQ-28.

Health Care Workers in the 2 general hospitals and in the health centers of Lamia and Larissa, as well as in the Regional University Hospital of Larissa participated in the study. 386 sufficiently filled in questionnaires were evaluated. Statistics was processed with SPSS (version 15.0). Level of statistical importance was considered at p < 0.05.

93 participants (24,1%) were men and 291 (75,4%) were women. The work load, the occasions of development and the collaboration with colleagues were the critical factors in which the nurses exhibited worse statistically significantly scores in comparison with the other groups of health professionals. In the factor “job satisfaction” the nurses had lower scores (intermediate =3, IQR=2-5) compared with non- nurses (intermediate = 5, IQR=3-6) p< 0,001. In the same parameters the workers in the hospitals presented with worse scores than the workers in the health centers. The anxiety level stress of nurses is high.

The nurses constitute the group of health care workers with the lower job satisfaction and the highest anxiety levels.