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Psychopathologic, neuropsychological and functional outcome measures during cognitive rehabilitation in schizophrenia: A prospective controlled study in a real-world setting

Published online by Cambridge University Press:  16 April 2020

A. Vita ,
L. De Peri ,
S. Barlati ,
P. Cacciani ,
M. Cisima ,
G. Deste ,
B.M. Cesana  and
E. Sacchetti
A. Vita*
Affiliation:
University of Brescia, School of Medicine, via Europa 11, 25123Brescia, Italy Department of Mental Health, Spedali Civili Hospital, University Psychiatric Unit II, Brescia, Italy
L. De Peri
Affiliation:
University of Brescia, School of Medicine, via Europa 11, 25123Brescia, Italy
S. Barlati
Affiliation:
Department of Mental Health, Spedali Civili Hospital, University Psychiatric Unit II, Brescia, Italy
P. Cacciani
Affiliation:
Department of Mental Health, Spedali Civili Hospital, University Psychiatric Unit I, Brescia, Italy
M. Cisima
Affiliation:
Department of Mental Health, Spedali Civili Hospital, University Psychiatric Unit II, Brescia, Italy
G. Deste
Affiliation:
University of Brescia, School of Medicine, via Europa 11, 25123Brescia, Italy
B.M. Cesana
Affiliation:
University of Brescia, School of Medicine, via Europa 11, 25123Brescia, Italy Department of Biomedical Sciences and Biotechnologies, Medical Statistics Division, University of Brescia, Brescia, Italy
E. Sacchetti
Affiliation:
University of Brescia, School of Medicine, via Europa 11, 25123Brescia, Italy Department of Mental Health, Spedali Civili Hospital, University Psychiatric Unit I, Brescia, Italy Center for Neurodegenerative Disorders and EULO, University of Brescia, Brescia, Italy
*
*Corresponding author. Tel.: +39 030 2184856; fax: +39 030 2184871. E-mail addresses: [email protected] (A. Vita).
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Abstract

Background

Cognitive dysfunction has been demonstrated in patients with schizophrenia, and this may affect patients’ functional outcome. The improvement of such dysfunction by means of cognitive remediation interventions has become a relevant target in the care of schizophrenia.

Objective

To assess the effectiveness of the cognitive subprograms of Integrated Psychological Therapy (IPT) on symptomatological, neuropsychological and functional outcome variables and to analyze the relationships between cognitive and functional outcome changes in schizophrenia.

Methods

Thirty-two patients with schizophrenia were assigned to cognitive remediation (IPT-cog) or usual rehabilitative interventions in a naturalistic setting of care. Clinical, neuropsychological and functional outcome variables were assessed at baseline and after 24 weeks of treatment.

Results

The IPT-cog group improved significantly more than the comparison group with respect to psychopathological and functional outcome variables. Moreover, only the IPT-cog group improved significantly in the neuropsychological domains of verbal and working memory, with specific significant correlations between neurocognitive performance and functional outcome changes.

Conclusions

The results of the study confirm the effectiveness of the cognitive remediation component of IPT in schizophrenia, and indicate that some of the changes in functional outcome may be mediated by improvement in specific cognitive domains.

Keywords

SchizophreniaCognitive dysfunctionCognitive remediationFunctional outcome
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 5 , August 2011 , pp. 276 - 283
Copyright
Copyright © Elsevier Masson SAS 2011

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