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Psychiatric clinical profiles and pharmacological interactions in COVID-19 inpatients referred to a consultation liaison psychiatry unit

Published online by Cambridge University Press:  13 August 2021

N. Arbelo ,
M. Sagué ,
H. López-Pelayo ,
S. Madero ,
J. Pinzón-Espinosa ,
G. Anmella ,
S. Gomes-Da-Costa ,
L. Ilzarbe ,
C. Llach  and
M. Cámara
...Show all authors
N. Arbelo*
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
M. Sagué
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
H. López-Pelayo
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
S. Madero
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
J. Pinzón-Espinosa
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
G. Anmella
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
S. Gomes-Da-Costa
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
L. Ilzarbe
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
C. Llach
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
M. Cámara
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
M.L. Imaz
Affiliation:
Unit Of Perinatal Mental Health, Hospital Clinic Barcelona, Barcelona, Spain
L. Pintor
Affiliation:
Department Of Psychiatry And Psychology, Institute Of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

The Coronavirus Disease 2019 (COVID-19) can affect mental health in different ways. There is little research about psychiatric complications in hospitalized patients with COVID-19.

Objectives

The aim of the study was to describe the psychiatric clinical profile and pharmacological interactions in COVID-19 inpatients referred to a Consultation-Liaison Psychiatry (CLP) unit.

Methods

This is a cross-sectional retrospective study, carried out at a tertiary hospital in Spain, in inpatients admitted because of COVID-19 and referred to our CLP Unit from March 17,2020 to April 28,2020. Clinical data were extracted from electronic medical records. The patients were divided in three groups depending on psychiatric diagnosis: delirium, severe mental illness (SMI) and non-severe mental illness (NSMI).

Results

Of 71 patients included (median [ICR] age 64 [54-73] years; 70.4% male), 35.2% had a delirium, 18.3% had a SMI, and 46.5% had a NSMI. Compared to patients with delirium and NSMI, patients with SMI were younger, more likely to be institutionalized and were administered less anti-COVID19 drugs. Mortality was higher among patients with delirium (21.7%) than those with SMI (0%) or NSMI (9.45%). The rate of side effects due to interactions between anti-COVID19 and psychiatric drugs was low, mainly drowsiness (4.3%) and borderline QTc prolongation (1.5%).

Conclusions

Patients affected by SMI were more often undertreated for COVID-19. However, the rate of interactions was very low, and avoidable with a proper evaluation and drug-dose adjustment. Half of the patients with SMI were institutionalized, suggesting that living conditions in residential facilities could make them more vulnerable to infection.

Disclosure

No significant relationships.

Keywords

COVID-19Consultation-Liaison PsychiatryPsychopharmacologydelirium
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S100
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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