Many time people get addicted to a drug like opiods when prescribed for some medical purpose. Neurobiological models of addiction has proposed cellular adaptation as mechanism of drug addiction. Excessive release of dopamine in NA due to drug intake produces euphoric sensation leading to pathological learning. Repeated use of drug increase glutametergic drive from prefrontal to NA cause compulsive seeking of drug in drug addicts. Is it possible to prevent medically induced addiction.

Pub med search was made by using key words, addiction model, dopamine, glutamate, anticraving medicine, oxidative stress.

Different antiglutametergic medication like ketamine, mementine, accomprosate modulate glutamatic excitation to prevent addiction. Natural medicine like N acetyle cystine and oxytocin have protective role . Typical antipsychotic can block surge of dopamine in NA.

When addictive drug has to be used inevitably for medical purpose it should be combined with other drugs to prevent development of addiction. First euphoria related to dopamine release in NA can be blocked by use of low dose typical antipsychotic or dopamine partial antagonist . NMDA is molecular target of various addictive drugs. Memtentine, ketamine or accomprosate can minimize effects of glutametergic plasticity. N accetyle cystine can restore glutamatergic pathway by its system of cystine- glutamate antiporter. It is source of glutathione largest anti oxidant system of body. Intranasal oxytocin can prevent addiction through its action on stress, learning, memory and intimacy. Intranasal oxytocin can be delivered directly to the brain.

Different strategies can be used to prevent medically induced addiction.