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Predictors of persistence of ultrahigh risk symptoms and predictors of transition into psychosis

Published online by Cambridge University Press:  16 April 2020

M. van der Gaag ,
J. Rietdijk ,
H. Ising ,
S. Dragt ,
R. Klaassen ,
D. Nieman ,
L. Wunderink  and
D.H. Linszen
M. van der Gaag
Affiliation:
Dept of Clinical Psychology, VU University Amsterdam, Amsterdam, The Netherlands Psychosis Research, Parnassia, The Hague, The Netherlands
J. Rietdijk
Affiliation:
Dept of Clinical Psychology, VU University Amsterdam, Amsterdam, The Netherlands
H. Ising
Affiliation:
Psychosis Research, Parnassia, The Hague, The Netherlands
S. Dragt
Affiliation:
Dept Early Psychosis, Academic Psychiatric Center, Amsterdam, The Netherlands
R. Klaassen
Affiliation:
Child Psychiatry, Rivierduinen Psychiatric Institute, Leiden, The Netherlands
D. Nieman
Affiliation:
Dept Early Psychosis, Academic Psychiatric Center, Amsterdam, The Netherlands
L. Wunderink
Affiliation:
Education and Research, Friesland Mental heakth Services, Leeuwarden, The Netherlands
D.H. Linszen
Affiliation:
Dept Early Psychosis, Academic Psychiatric Center, Amsterdam, The Netherlands

Abstract

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Aims

To determine predictors of transition from ultrahigh risk into psychosis.

Method

The Dutch EDIE trial has included 201 people with an ultrahigh risk for psychosis. These were included with both a referral based strategy and a screening all help-seeking people strategy. The study had a 24 month inclusion period and an 18 mont follow-up period with each patient. The preliminary results are presented.

Results

A loogistic regression was performed over 164 cases. 29 patients developed a psychosis.

Predictor variables were depression, social intercation anxiety, positive symptoms on the CAARMS, negative symptoms on the CAARMS, quality of life, social functioning, genetic risk, and the personal beliefs about illness.

The backward logistice regression (likelyhood ratio) discarded four variables. Predictors of psychosis were depression, positive symptoms, genetic liability and beliefs about illness at basline.

Conclusions

People with hihd scores on depression and positive symptoms are likely to develop a psychosis. Also those who have a psychotic parent and positive symptoms a more lekly to make a transition. Interestingly people that consider their condition as hopeless, feel entrapped by their condition, excluded by other pople and not in control of symptoms also have a heightened chance for developing psychosis in this sample.

Type
S21-01
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 2086
Copyright
Copyright © European Psychiatric Association 2011
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