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Prediction of Response to Bupropion Treatment - the Early Change of Prefrontal QEEG Cordance. Open Label Study

Published online by Cambridge University Press:  16 April 2020

M. Bares ,
M. Brunovsky ,
T. Novak ,
M. Kopecek ,
P. Stopkova ,
P. Sos  and
C. Höschl
M. Bares
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
M. Brunovsky
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
T. Novak
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
M. Kopecek
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic Center for Excellence for Research & Treatment Bipolar Disorder, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapell Hill, USA
P. Stopkova
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
P. Sos
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
C. Höschl
Affiliation:
Prague Psychiatric Centre, Prague, Czech Republic The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic

Abstract

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Aims:

Previous studies demonstrated predictive effect of reduction of prefrontal cordance for non-resistant outpatients or resistant inpatients treated by various antidepressants or venlafaxine. The aim of the present study was to examine whether the reduction of theta prefrontal QEEG cordance value after 1 week of bupropion administration is associated with response to 4 weeks treatment in patients with resistant depressive disorder. We extended our previous pilot data.

Methods:

We analyzed 18 inpatients, who finished 4-week treatment with venlafaxine. EEG data were monitored at baseline and after 1 week of treatment. QEEG cordance was computed at 3 frontal electrodes in theta frequency band. Depressive symptoms were assessed using Montgomery-Åsberg Depression Rating Scale (MADRS).

Results:

Nine of 11 responders (reduction of MADRS ≥50%) and no one of 7 non-responders decreased prefrontal QEEG cordance value after the first week of treatment. Positive and negative predictive value (PPV, NPV) of cordance reduction for response to treatment was 1.0 (95% CI, 0.8-1.0) and 0.78 (95% CI, 0.57-0.78), respectively.

Conclusions:

Based on our results, the prefrontal QEEG cordance might be helpful in the prediction of the response to bupropion treatment in resistant patients.

This study was supported by a grant from Internal Grant Agency of Ministry of Health of Czech Republic No. NR/9330-3 and a grant from Ministry of Health of Czech Republic MZ0PCP2005.

Type
P01-222
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E610
Copyright
Copyright © European Psychiatric Association 2009
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