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Possible association between high social anxiety level and genetic markers in young adult Internet addicts

Published online by Cambridge University Press:  01 September 2022

A. Trusova ,
A. Gvozdetckii ,
T. Merkulova ,
N. Chuprova ,
M. Solovieva ,
S. Grechany ,
V. Soldatkin ,
A. Yakovlev ,
P. Ponizovsky  and
R. Iluyk
...Show all authors
A. Trusova*
Affiliation:
Saint Petersburg State University, Department Of Medical Psychology And Psychophysiology, Saint Petersburg, Russian Federation
A. Gvozdetckii
Affiliation:
North-Western State Medical University named after I.I. Mechnikov, Department Of Psychiatry And Addiction, Saint-Petersburg , Russian Federation
T. Merkulova
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
N. Chuprova
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
M. Solovieva
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
S. Grechany
Affiliation:
Saint Petersburg State Pediatric Medical University, Department Of Psychiatry And Addictology, Saint Petersburg, Russian Federation
V. Soldatkin
Affiliation:
Rostov State Medical University, Department Of Psychiatry, Addictology And Medical Psychology, Rostov-on-Don, Russian Federation
A. Yakovlev
Affiliation:
Lipetsk Regional Addiction Hospital, Department Of Addictology, Lipetsk, Russian Federation
P. Ponizovsky
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Department Of Therapy Of Mental Disorders Complicated By Addiction Diseases, Moscow, Russian Federation
R. Iluyk
Affiliation:
Bekhterev National Medical Research Center for Psychiatry and Neurology, Department Of Addictology, Saint Petersburg, Russian Federation
A. Egorov
Affiliation:
Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Laboratory Of Neurophysiology And Pathology Of Behavior, St.Petersburg, Russian Federation
E. Krupitsky
Affiliation:
Bekhterev National Medical Research Center for Psychiatry and Neurology, Department Of Addictology, Saint Petersburg, Russian Federation
A. Kibitov
Affiliation:
Serbsky National Medical Research Center on Psychiatry and Addictions, Laboratory Of Molecular Genetics, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Internet addiction (IA) is a rapidly growing disorder especially among adolescents and young adults. Social anxiety is one of the risk factors for IA. Also, genes involved in dopaminergic and serotoninergic systems are among the candidate genes most frequently associated with IA.

Objectives

The study aimed to investigate the association between social anxiety level and genetic markers in young adult Internet addicts.

Methods

IA group included 44 people (Chen/Chinese Internet Addiction Scale (CIAS) score ≥ 65), 75,0% males), the average age 22,0 [18,0;25,0] y.o. (Md [Q1; Q3]). Healthy control group (CIAS score was less 65) included 120 people, (73,3% males), the average age 23,0 [22,0;24,0] y.o. Psychometric measures: Liebowitz Social Anxiety Scale (LSAS). Genetic markers: rs2072450 in GRIN2A, rs2832407 in GRiK-GluR5, HUMTH01 in TH01(S<9, L>=9 repeats). The impact of genotypes on social anxiety scores was identified using Proportional Odd Logit modeling taking into account group affiliation.

Results

Group of IA reported significantly higher levels in almost all LSAS measures including total score. We found that carriers of the genotypes rs2072450 CC (p=0.004 vs.CA/AA), rs2832407 CC (p=0.023 vs AA), and TH01 SS (p=0.013 vs. LL) scored significantly higher of LSAS total in the IA group. There were no significant differences in the healthy controls group.

Conclusions

The rs2072450(CC) in GRIN2A, rs2832407(CC) in GRiK-GluR5, and HUMTH01 in TH01(SS) genotypes may be possibly associated with higher social anxiety levels in Internet addicts.

Disclosure

The study was supported by the Russian Foundation for Basic Research (RFBR), project #18-29-22079.

Keywords

internet addictionsocial anxietygenetic factors
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S814
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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