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Platelet serotonin-binding and dexamethasone suppression test in melancholia and dysthymia

Published online by Cambridge University Press:  16 April 2020

C Gastó ,
J Vallejo ,
JM Menchón ,
R Catalán ,
A Otero ,
M Jesus Martínez de Osaba  and
F Ribera
C Gastó
Affiliation:
Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona Subdivision of Psychiatry and Psychology, Hospital Clinic i Provincial, Barcelona
J Vallejo
Affiliation:
Hospital de Bellvitge, Barcelona and Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona
JM Menchón
Affiliation:
Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona
R Catalán
Affiliation:
Subdivision of Psychiatry and Psychology, Hospital Clinic i Provincial, Barcelona
A Otero
Affiliation:
Department of Psychiatry and Medical Psychobiology, University of Barcelona, Barcelona Subdivision of Psychiatry and Psychology, Hospital Clinic i Provincial, Barcelona
M Jesus Martínez de Osaba
Affiliation:
Hormonal Laboratory, Hospital Clinic, Barcelona, Spain
F Ribera
Affiliation:
Hormonal Laboratory, Hospital Clinic, Barcelona, Spain
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Summary

Platelet serotonin-binding (Bmax), using tritiated-seroionin as the ligand, was determined in 75 patients suffering from major depression with melancholia and in 26 patients diagnosed from dysthymic disorder. Twenty-five normal subjects were used as a control group. The melancholic group had significantly lower Bmax values (mean: 6.7 ± 6.1 pmol/108 platelets) than either dysthymic (9.3 ± 3.9 pmol/108 platelets) or control (9.2 ± 4.8 pmol/108 platelets) groups, while there were no significant differences between the two latter groups. There was also a significant difference on postdexamethasone Cortisol between melancholic (6.3 ± 7.1 μg/dL) and dysthymic (1.4 ± 1.4 μg/dL) groups, with a higher rate of nonsuppressors in melancholic groups. Although both tests were abnormal in the melancholic group, no relationship was found between platelet serotonin-binding and the dexaniethasone suppression test.

Keywords

platelet serotonin-bindingdexamethasone suppressionmelancholiadysthymia
Type
Original article
Information
European Psychiatry , Volume 9 , Issue 6 , 1994 , pp. 281 - 287
Copyright
Copyright © European Psychiatric Association 1994

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