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Platelet serotonin decrease in panic disorder with obsessive compulsive symptoms

Published online by Cambridge University Press:  16 April 2020

D Servant ,
D Bailly ,
C Perret ,
J Vignau  and
PJ Parquet
D Servant
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
D Bailly
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
C Perret
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
J Vignau
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
PJ Parquet
Affiliation:
Consultation Spécialisée sur l’Anxiété, Unité de Psychopathologie et Alcoologie, CHU de Lille, Hôpital de la Charité, 196 boulevard Montebello, 59037 Lille Cedex, France
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Summary

Platelet 5-HT levels were determined by fluorescent orthophthaldehyde assay in 33 panic disorder patients with and without obsessive compulsive symptoms (PD + OCS: n = 16; PD-OCS: n = 17) according to DSM III-R criteria, and compared With those of 38 healthy controls. Mean platelet levels were significantly lower in PD + OCS than in PD-OCS patients. The results are discussed in relation to serotonergic dysfunction linked to PD and OCS comorbidity.

Keywords

serotoninpanic disorderobsessive-compulsive disorderplatelet
Type
Original article
Information
European Psychiatry , Volume 7 , Issue 1 , 1992 , pp. 27 - 31
Copyright
Copyright © Elsevier, Paris 1992

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