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Plasma Concentrations Of Endocannabinoids And Congeners In a Primary Care Sample Of Depressed Patients: Influence Of Biological Variables, Severity And Antidepressant Medication

Published online by Cambridge University Press:  23 March 2020

P. Romero-Sanchiz ,
R. Nogueira-Arjona ,
F. Mayoral-Cleríes ,
F. Rivas-Guerrero ,
P. Araos-Gómez ,
M. Pedraz-Fernández ,
A. Serrano-Criado ,
F.J. Pavón-Morón ,
R. De la Torre-Fornell  and
A. Pastor-Bosch
...Show all authors
P. Romero-Sanchiz*
Affiliation:
IBIMA – Hospital Regional Universitary Malaga, Mental Health, Málaga, Spain
R. Nogueira-Arjona
Affiliation:
IBIMA – University of Malaga, Personality – assessment and psychological treatment, Málaga, Spain
F. Mayoral-Cleríes
Affiliation:
IBIMA – Hospital Regional Universitary Malaga, Mental Health, Málaga, Spain
F. Rivas-Guerrero
Affiliation:
IBIMA – Hospital Regional Universitary Malaga, Mental Health, Málaga, Spain
P. Araos-Gómez
Affiliation:
IBIMA, Neropsychopharmacology, Malaga, Spain
M. Pedraz-Fernández
Affiliation:
IBIMA, Neropsychopharmacology, Malaga, Spain
A. Serrano-Criado
Affiliation:
IBIMA, Neropsychopharmacology, Malaga, Spain
F.J. Pavón-Morón
Affiliation:
IBIMA, Neropsychopharmacology, Malaga, Spain
R. De la Torre-Fornell
Affiliation:
IMIM, Integrated Pharmacology and Systems Neurosciences, Barcelona, Spain
A. Pastor-Bosch
Affiliation:
IMIM, Integrated Pharmacology and Systems Neurosciences, Barcelona, Spain
F. Rodríguez de Fonseca
Affiliation:
IBIMA, Neropsychopharmacology, Malaga, Spain
*
*Corresponding author.

Abstract

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Introduction

Endocannabinoid system has been highlighted as one of the most relevant research topics by neurobiologists, pharmacists, basic scientists and clinicians. The association between endocannabinoids and its congeners and mood disorders is relatively recent. However, evidence from both clinical and preclinical studies is increasing and many researchers point out endocannabinoid system and particularly endocannabinoids and congeners as promising pharmacological targets.

Aims and objectives

The main objective of this study is to compare the plasma concentrations of endocannabinoids and congeners between a sample of patients with depression and a sample of control subjects, and the influence of variables such as age, body mass index, gender, severity of symptoms, and antidepressant medication.

Method

Plasma concentrations of endocannabinoids and congeners will be analyzed in 69 patients with depression from primary care and 47 controls using mass spectrometry analysis.

Results

Statistically significant differences in 2-arachidonoylglycerol and monoacylglycerols were found between both samples. Somatic symptoms of depression seems to be more related to these compounds that to cognitive-affective symptoms. In addition, differences between mildly and moderately depressed patients were found in concentrations of AEA, LEA, DGLEA and POEA. Patients with antidepressant medication showed higher levels of 2-AG, DGLEA and OEA.

Conclusions

The results of this study provide evidence supporting the hypothesis that in depression there is a dysregulation of the inflammatory signaling and, consequently the immune system. The results of this study could also support the realization of translational research to better understand the mechanisms of this widely distributed system.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV539
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S422 - S423
Copyright
Copyright © European Psychiatric Association 2016
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