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Peripheral serotonin uptake is related to neural activation in the cingulate cortex

Published online by Cambridge University Press:  16 April 2020

C. Scharinger ,
C. Kasess ,
W. Huf ,
K. Kalcher ,
H. Esterbauer ,
H. Sitte ,
S. Kasper ,
E. Moser  and
L. Pezawas
C. Scharinger
Affiliation:
Devision of Biological Psychiatry Department of Psychiatry and Psychotherapy, Vienna, Austria
C. Kasess
Affiliation:
MR Centre of Excellence Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
W. Huf
Affiliation:
Devision of Biological Psychiatry Department of Psychiatry and Psychotherapy, Vienna, Austria MR Centre of Excellence Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria Department of Statistics and Probability Theory, Vienna University of Technology, Vienna, Austria
K. Kalcher
Affiliation:
Devision of Biological Psychiatry Department of Psychiatry and Psychotherapy, Vienna, Austria MR Centre of Excellence Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria Department of Statistics and Probability Theory, Vienna University of Technology, Vienna, Austria
H. Esterbauer
Affiliation:
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
H. Sitte
Affiliation:
Institute of Pharmacology, Center for Biomolecular Medicine and Pharmacology, Medical Universitiy of Vienna, Vienna, Austria
S. Kasper
Affiliation:
Devision of Biological Psychiatry Department of Psychiatry and Psychotherapy, Vienna, Austria
E. Moser
Affiliation:
MR Centre of Excellence Centre for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
L. Pezawas
Affiliation:
Devision of Biological Psychiatry Department of Psychiatry and Psychotherapy, Vienna, Austria

Abstract

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Introduction

Maximal serotonin transporter (5-HTT) densities have been found in the cingulate cortex, a cortical region that has been critically implicated in emotion processing and the pathophysiology of Major Depressive Disorder. Furthermore, serotonin (5-HT) re-uptake inhibition is the first line strategy in the treatment of depression.

Objectives

Since 5-HTTs are not restricted to neuronal cells, 5-HT uptake velocity (Vmax) can be easily measured on blood platelets subserving as peripheral model of neuronal 5-HTT function and related measures of neural activation.

Aims

To determine whether peripheral 5-HTT uptake velocity is related to neural activation in the cingulate cortex during emotion processing.

Methods

48 healthy subjects underwent an fMRI paradigm comprising emotional (angry/fearful faces and scenes) and neutral stimuli (simple shapes). 5-HT Vmax was determined in platelets. Subjects were genotyped for a common triallelic polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR).

Results

Significant negative correlations between Vmax and BOLD-signal in the anterior and posterior portion of the cingulate cortex have been found. Cluster maxima within both regions were detected in the subgenual anterior cortex (−1.5, 28.5, −3.5, t = −3.77) and the ventral posterior cingulate cortex (−4.5, −49.5,14.5, t = −3.06). Genotype did not impact on this relationship.

Conclusions

Our results indicate a clear dependency between a peripheral marker, platelet 5-HT uptake velocity, and neural activity in portions of the cingulate cortex for the first time.

Type
P02-89
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 684
Copyright
Copyright © European Psychiatric Association 2011
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