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Pathogenic Role of Proinflammatory Cytokines in the Development of Chronic Cerebral Ischemia

Published online by Cambridge University Press:  15 April 2020

D. Usmanova*
Affiliation:
Neurology, Tashkent institute for postgraduate medical education, Tashkent, Uzbekistan

Abstract

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Background

Cerebral ischemia is the most frequent cause of the brain functions disorders accompanied by immune changes. The multiple studies show participation of the inflammation process in the atherogenesis and development of the chronic cerebral ischemia (CCI).

Purpose

To study characteristics of the proinflammatory cytokines (TNF-α, IL-1β, IL-6) in the patients with CCI with regard to the genesis of the development.

Material and Methods

There were studied 133 patients who were divided into 2 groups in relation to the pathogenesis of the CCI development. Group 1 included 65 (42,5%) patients with CCI developed predominantly on the basis of arterial hypertension (AH). Group 2 consisted of 68 (44,5%) patients with CCI, developed mainly in cerebral atherosclerosis. The control group of 20 (13,0%) healthy subjects was made for comparison of immunological examinations. The measurement of the cytokine contents (TNF- α, IL-1β, IL-6) in the peripheral blood serum was performed with IFA method with use of commercial tests – systems 'Vector – Best”, Novosibirsk, RF,2013.

Results

The level of TNF-α in the blood serum in the patients of group 1 and 2 was increased 2,9 (6,3±0,76 pg/ml) and 2,12 times (4,6±0,48 pg/ml), respectively, in the control group only 2,15±0,23 pg/ml. In group 1 IL-1β was increased 1,8 times (11,4±1,10 pg/ml), in group 2 – 1,4 times (8,9±0,64 pg/ml). IL-6 in group 1 was 7,4±0,86 pg/ml, while in group 2 was 6,5±0,62 pg/ml.

Conclusion

In the pathogenesis of CCI of the hypertonic and atherosclerotic genesis the proinflammatory cytokines have important role.

Type
Article: 1562
Copyright
Copyright © European Psychiatric Association 2015
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