The concept of Self has brought about major interdisciplinary interaction as Neuroscientific, Philosophic and psychological paradigms clash. The psychiatric epistemic paradigm of insight, depersonalization, dissociation, passivity experience and even schizophrenia reveals clear links to some important concepts that depend on this one. First we aim to present in a clear flowchart a short conceptual history of the Self from Aristotle’ till today. We’ll present Stoics, Descartes, Locke and Hume contributions to the clarification of this concept. As will be shown, this vast theoretical background was ground not only to its pervasiveness in psychopathology and psychiatric nosology but also to conceptual blur. Also we’ll present which different terms in psychiatry were influenced by the foundation and development of different theories of Self. Some concepts have weakened and were dropped (e.g. Multiple Personality) while others have received a greater prominence (e.g. insight). A special focus will be given to the intersection of the neuro-scientific and philosophical paradigm. It seems rather than destroying and weaken each other they can support each ones. We believe a clearer understanding of the Self will offer psychiatrists a clearer understanding in their clinical practice.