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P-804 - Neurofunctional Basis of Social Cognition in Subclinical Paranoid Ideation and Social Anxiety

Published online by Cambridge University Press:  15 April 2020

V. Villalta-Gil ,
I. Meléndez ,
J. Radua ,
C. Stephan-Otto ,
M.A. Fullana ,
I. Ruiz-Ripoll  and
S. Surguladze
V. Villalta-Gil
Affiliation:
CIBERSAM, Madrid Psiquiatria i Medicina Legal, Universidad Autónoma de Barcelona, Spain, Cerdanyola del Vallès
I. Meléndez
Affiliation:
CIBERSAM, Madrid Fundació Sant Joan de Déu, Esplugues de Llobregat, Spain
J. Radua
Affiliation:
CIBERSAM, Madrid Institute of Psychiatry, King's College, London, UK FIDMAG, Sant Boi de Llobregat
C. Stephan-Otto
Affiliation:
CIBERSAM, Madrid Fundació Sant Joan de Déu, Esplugues de Llobregat, Spain
M.A. Fullana
Affiliation:
Psiquiatria i Medicina Legal, Universidad Autónoma de Barcelona, Spain, Cerdanyola del Vallès Institute of Psychiatry, King's College, London, UK Parc de Salut Mat, Barcelona, Spain
I. Ruiz-Ripoll
Affiliation:
Parc de Salut Mat, Barcelona, Spain
S. Surguladze
Affiliation:
Institute of Psychiatry, King's College, London, UK Cygnet Health Care, London, UK

Abstract

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Introduction

Impaired social functioning is a hallmark characteristic of several mental disorders including those characterized by paranoid ideation (P) and social anxiety (SA). Social deficits have been related to impaired social cognition.

Objectives

To investigate the neurofunctional basis of social cognition in people with subclinical P and SA.

Methods

13 healthy participants with high paranoid ideation; 12 healthy participants with high social anxiety. Procedures and Instruments: Paranoid Thoughts Scale, Liebowitz Social Anxiety Scale, Cardiff Anomalous Perceptions Scale. Brain response to social stimuli was investigated with two event-related fMRI experiments with implicit processing of facial. expressions of happiness and anger in two different intensities, and with faces expressing no emotion.

Results

People with P recruit differentially and positively the Left Lingual (p < 0,05 FWEcorr), and close to significant (p < 0,06 FWEcorr) the Right Caudate when processing neutral faces. People with SA only showed significant positive differences (p < 0,05 FWEcorr) in the Right Inferior frontal gyrus when processing anger stimuli at 100%. When comparing both groups, we did not find significant differences.

Conclusions

The preliminary results indicate a stronger recruitment of emotional and visual areas in P subjects when processing neutral faces and a stronger recruitment of cognitive processing areas in SA subjects when processing angry faces.

Type
Abstract
Information
European Psychiatry , Volume 27 , Issue S1: Abstracts of the 20th European Congress of Psychiatry , 2012 , pp. 1
Copyright
Copyright © European Psychiatric Association 2012
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